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Gc Gene Detail
Summary
  • Symbol
    Gc
  • Name
    vitamin D binding protein
  • Synonyms
    DBP, vitamin D binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:95669
    NCBI Gene: 14473
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:89565381-89605757 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.32 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95669
protein coding gene Chr5:89565370-89605757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029715
protein coding gene Chr5:90431331-90469159 (-)
A/J MGP_AJ_G0029681
protein coding gene Chr5:86878006-86912415 (-)
AKR/J MGP_AKRJ_G0029627
protein coding gene Chr5:89733271-89768348 (-)
BALB/cJ MGP_BALBcJ_G0029691
protein coding gene Chr5:87781757-87816994 (-)
C3H/HeJ MGP_C3HHeJ_G0029414
protein coding gene Chr5:90077262-90116223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030145
protein coding gene Chr5:94106828-94140128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027381
protein coding gene Chr5:82648304-82685004 (-)
CAST/EiJ MGP_CASTEiJ_G0028824
protein coding gene Chr5:89489160-89523070 (-)
CBA/J MGP_CBAJ_G0029383
protein coding gene Chr5:97262900-97302986 (-)
DBA/2J MGP_DBA2J_G0029528
protein coding gene Chr5:86943618-86976851 (-)
FVB/NJ MGP_FVBNJ_G0029487
protein coding gene Chr5:85848847-85890029 (-)
LP/J MGP_LPJ_G0029616
protein coding gene Chr5:90834924-90869834 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029516
protein coding gene Chr5:102278996-102321373 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030179
protein coding gene Chr5:89250316-89288227 (-)
PWK/PhJ MGP_PWKPhJ_G0028543
protein coding gene Chr5:86003266-86037939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028378
protein coding gene Chr5:88655735-88686394 (-)
WSB/EiJ MGP_WSBEiJ_G0028903
protein coding gene Chr5:89659892-89699903 (-)



Homology
more
  • Human Ortholog
    GC, GC vitamin D binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GC, GC vitamin D binding protein
  • Synonyms
    DBP, DBP/GC, DBP-maf, GcMAF, Gc-MAF, GRD3, HEL-S-51, VDB, VDBG, VDBP
  • Links
    NCBI Gene ID: 2638
    neXtProt AC: NX_P02774
    UniProt: P02774

  • Chr Location
    4q13.3; chr4:71741693-71805520 (-)  GRCh38

  • MGI Vertebrate Homology
    Gc stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: GC
  • Gene Tree
    Gc
Human Diseases
more
  • Diseases
    11 with human GC associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene show an essentially normal phenotype. However, they have an increased sensitivity to vitamin D deficiency in the diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035540 Ensembl Gene Model | MGI Sequence Detail 40377 C57BL/6J ±  kb
    transcript ENSMUST00000049209 Ensembl | MGI Sequence Detail 1801 Not Applicable  
    polypeptide ENSMUSP00000046636 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      Genomic 2
      cDNA 192
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10014
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:338939 Graham-Paquin AL, et al., ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development. Nucleic Acids Res. 2023 Aug 11;51(14):7314-7329

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory