Cyp1a1 MGI Mouse Gene Detail - MGI:88588 - cytochrome P450, family 1, subfamily a, polypeptide 1

Symbol

Cyp1a1
Name

cytochrome P450, family 1, subfamily a, polypeptide 1
Synonyms

cytochrome P450 subfamily I, polypeptide 1, P450-1

Feature Type

protein coding gene
IDs

MGI:88588
NCBI Gene: 13076
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:57595211-57611107 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 31.34 cM
Mapping Data

12 experiments

SNPs within 2kb

357 from dbSNP Build 142
Strain Annotations

19
PCR

2
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88588	protein coding gene	Chr9:57595211-57611107 (+)
129S1/SvImJ	ENSMUSG00200034541	protein coding gene	Chr9:54720809-54736705 (+)
A/J	ENSMUSG00195039731	protein coding gene	Chr9:54420855-54436766 (+)
AKR/J	ENSMUSG00220028900	protein coding gene	Chr9:54561680-54577586 (+)
BALB/cJ	ENSMUSG00180016672	protein coding gene	Chr9:54534550-54550456 (+)
C3H/HeJ	ENSMUSG00175021822	protein coding gene	Chr9:54547668-54563575 (+)
C57BL/6NJ	ENSMUSG00215024071	protein coding gene	Chr9:54527909-54543815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032279	protein coding gene	Chr9:54391553-54397863 (+)
CAST/EiJ	ENSTCUG00005018874	protein coding gene	Chr9:54455101-54471858 (+)
CBA/J	ENSMUSG00210040113	protein coding gene	Chr9:54656086-54672003 (+)
DBA/2J	ENSMUSG00185041007	protein coding gene	Chr9:54678344-54694232 (+)
FVB/NJ	ENSMUSG00205036419	protein coding gene	Chr9:54985132-55001020 (+)
JF1/MsJ	ENSUMUG00000029602	protein coding gene	Chr9:54697117-54713994 (+)
LP/J	ENSMUSG00230033032	protein coding gene	Chr9:54920584-54936480 (+)
NOD/ShiLtJ	ENSMUSG00190043236	protein coding gene	Chr9:54746346-54762237 (+)
NZO/HlLtJ	ENSMUSG00225027640	protein coding gene	Chr9:54959218-54975125 (+)
PWK/PhJ	ENSLUMG00010032356	protein coding gene	Chr9:54655010-54672279 (+)
SPRET/EiJ	ENSMSPG00010024732	protein coding gene	Chr9:55702875-55709209 (+)
WSB/EiJ	ENSIUOG00005038135	protein coding gene	Chr9:54159291-54175180 (+)

Human Ortholog

CYP1A1, cytochrome P450 family 1 subfamily A member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP1A1, cytochrome P450 family 1 subfamily A member 1
Synonyms

AHH, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
Links

HGNC:2595

NCBI Gene ID: 1543

UniProt: P04798
Chr Location

15q24.1; chr15:74719542-74725536 (-) GRCh38

MGI Vertebrate Homology

Cyp1a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP1A1
Gene Tree

Cyp1a1

Diseases

39 with human CYP1A1 associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				ankylosing spondylitis IDs ankylosing spondylitis DOID:7147 EFO:0003898 ICD10CM:M45 ICD9CM:720.0 MESH:D013167 NCI:C84564 OMIM:PS106300 ORDO:825 UMLS_CUI:C0038013
				Behcet's disease IDs Behcet's disease DOID:13241 EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 ICD9CM_2006:136.1 MESH:D001528 NCI:C34416 OMIM:109650 UMLS_CUI:C0004943
				biliary tract cancer IDs biliary tract cancer DOID:4607 DOID:8092 ICD10CM:C24.9 ICD9CM:156.9 MESH:D001661 UMLS_CUI:C0005426 UMLS_CUI:C0750952
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				bronchitis IDs bronchitis DOID:6132 DOID:13503 DOID:13504 DOID:13707 DOID:13728 DOID:13729 DOID:5049 DOID:6130 DOID:6131 DOID:9982 DOID:9983 ICD10CM:J20 ICD10CM:J40 ICD10CM:J42 ICD9CM:466.0 ICD9CM:490 ICD9CM:491 ICD9CM:491.9 MESH:D001991 MESH:D029481 NCI:C26722 NCI:C26932 NCI:C2911 UMLS_CUI:C0006277 UMLS_CUI:C0008677 UMLS_CUI:C0149514
				chronic myeloid leukemia IDs chronic myeloid leukemia DOID:8552 DOID:8551 DOID:8606 EFO:0000339 ICD9CM:205.1 KEGG:05220 MESH:D015464 NCI:C9128 OMIM:608232 ORDO:521
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				clubfoot IDs clubfoot DOID:11836 DOID:0001874 ICD10CM:Q66.89 ICD9CM:754.51 MESH:D003025 NCI:C84641 OMIM:119800 UMLS_CUI:C0009081
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				end stage renal disease IDs end stage renal disease DOID:783
				endometrial cancer IDs endometrial cancer DOID:1380 DOID:5654 EFO:0004230 ICD10CM:C54.1 KEGG:05213 MESH:D016889 NCI:C27815 NCI:C3012 OMIM:608089 UMLS_CUI:C0007103 UMLS_CUI:C0014170
				esophageal cancer IDs esophageal cancer DOID:5041 DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				gallbladder cancer IDs gallbladder cancer DOID:3121 DOID:8090 DOID:8157 ICD10CM:C23 ICD9CM:156.0 MESH:D005706 NCI:C3048 NCI:C35676 NCI:C7481 UMLS_CUI:C0016978 UMLS_CUI:C0153452 UMLS_CUI:C0278806
				Graves' disease IDs Graves' disease DOID:12361 EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 UMLS_CUI:C0018213
				head and neck cancer IDs head and neck cancer DOID:11934 MESH:D006258 NCI:C3077 UMLS_CUI:C0018671
				hypospadias IDs hypospadias DOID:10892 ICD10CM:Q54 MESH:D007021 NCI:C40341 OMIM:146450 OMIM:300633 OMIM:300758 OMIM:300856 ORDO:440 UMLS_CUI:C0848558
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 NCI:C194105 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				oral cavity cancer IDs oral cavity cancer DOID:8618 DOID:0050627 DOID:8617 DOID:9049 DOID:9055 ICD10CM:C04 ICD10CM:C04.0 ICD10CM:C04.1 ICD9CM:144 ICD9CM:144.0 ICD9CM:144.1 ICD9CM:144.9 NCI:C194037 NCI:C194038 NCI:C9318 UMLS_CUI:C0153368 UMLS_CUI:C0153369 UMLS_CUI:C0496758
				oral squamous cell carcinoma IDs oral squamous cell carcinoma DOID:0050866
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				periodontitis IDs periodontitis DOID:824 EFO:0000649 ICD10CM:K05.3 MESH:D010518 NCI:C34918 UMLS_CUI:C0031099
				pneumonia IDs pneumonia DOID:552 DOID:10509 DOID:11742 DOID:5871 MESH:D011014 NCI:C3333 UMLS_CUI:C0032285
				polycystic ovary syndrome IDs polycystic ovary syndrome DOID:11612 EFO:0000660 ICD10CM:E28.2 ICD9CM:256.4 MESH:D011085 NCI:C26862 OMIM:184700 UMLS_CUI:C0032460
				porphyria cutanea tarda IDs porphyria cutanea tarda DOID:3132 ICD10CM:E80.1 MESH:D017119 NCI:C27725 OMIM:176090 OMIM:176100 ORDO:101330 UMLS_CUI:C0162566
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				psoriasis IDs psoriasis DOID:8893 EFO:0000676 ICD10CM:L40 MESH:D011565 NCI:C3346 OMIM:PS177900 UMLS_CUI:C0033860
				psoriatic arthritis IDs psoriatic arthritis DOID:9008 EFO:0003778 ICD10CM:L40.5 ICD9CM:696.0 MESH:D015535 NCI:C61277 UMLS_CUI:C0003872
				reactive arthritis IDs reactive arthritis DOID:6196 DOID:10148 DOID:11891 DOID:13318 DOID:13519 DOID:13782 DOID:13783 DOID:13784 DOID:13785 DOID:6194 DOID:9760 ICD10CM:M02.10 ICD10CM:M02.3 ICD9CM:099.3 ICD9CM:711.3 ICD9CM:711.30 MESH:D016918 NCI:C34975 UMLS_CUI:C0035012 UMLS_CUI:C0152085
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134
				Sjogren's syndrome IDs Sjogren's syndrome DOID:12894 DOID:416 ICD10CM:M35.0 ICD9CM:710.2 MESH:D012859 NCI:C26883 NCI:C70647 OMIM:270150 UMLS_CUI:C0086981 UMLS_CUI:C1527336
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
1 images
58 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

5
Targeted

15
Genomic Mutations

3 involving Cyp1a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.

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All GO Annotations

138
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

118
cDNA Data

16
Literature Summary

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyp1a1

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS23230.1

Ensembl

ENSMUSG00000032315 (Evidence)
NCBI Gene

13076

			Length	Strain/Species	Flank
genomic	13076	NCBI Gene Model \| MGI Sequence Detail	15897	C57BL/6J	± kb
transcript	NM_009992	RefSeq \| MGI Sequence Detail	2716	ZRU/MplStud
polypeptide	P00184	UniProt \| EBI \| MGI Sequence Detail	524	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006101 cytochrome P450 1A1

(term hierarchy)
EC

1.14.14.1, 4.2.1.152
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR008066 Cytochrome P450, E-class, group I, CYP1

IPR036396 Cytochrome P450 superfamily
GlyGen

P00184 2 sites, 1 O-linked glycan (1 site)

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All nucleic 33

Genomic 7

cDNA 17

Primer pair 6

Other 3

Microarray probesets 4

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MGD-MRK-13109, MGD-MRK-2302

Summaries

All 184

Developmental Gene Expression 13

Gene Ontology 18

Phenotypes 58
Earliest

J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
Latest

J:388916 Xia R, et al., Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways. iScience. 2025 May 16;28(5):112355

TSS for Cyp1a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85322	Chr9:57604895-57604899 (+)	9,686 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24