About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
MGI:88588
22 phenotypes from 4 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn
B6.129P2-Cyp1a1tm1.1Dwn 		abnormal hemoglobin content J:163973
abnormal liver physiology J:88957
abnormal xenobiotic pharmacokinetics J:163973
decreased hematocrit J:163973
decreased lymphocyte cell number J:163973
decreased physiological sensitivity to xenobiotic J:89337
decreased spleen weight J:163973
decreased susceptibility to xenobiotic induced morbidity/mortality J:89337
decreased thymus weight J:163973
increased circulating alanine transaminase level J:163973
increased circulating aspartate transaminase level J:163973
increased hemoglobin content J:163973
increased liver weight J:163973
increased neutrophil cell number J:163973
increased physiological sensitivity to xenobiotic J:147150, J:163973
increased susceptibility to weight loss J:163973
Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn
involves: 129P2/OlaHsd * C57BL/6 		decreased leukocyte cell number J:122409
enlarged liver J:122409
increased circulating alanine transaminase level J:122409
increased circulating aspartate transaminase level J:122409
small spleen J:122409
small thymus J:122409
Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:59398
Cyp1a1tm2.1Dwn/Cyp1a1tm2.1Dwn
B6.129X1-Cyp1a1tm2.1Dwn 		normal homeostasis/metabolism phenotype J:163973
Cyp1a1tm3.1Dwn/Cyp1a1tm3.1Dwn
B6.129X1-Cyp1a1tm3.1Dwn 		increased physiological sensitivity to xenobiotic J:163973
Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
B6.129X1-Cyp1a1tm4.1Dwn 		abnormal hemoglobin content J:163973
abnormal xenobiotic pharmacokinetics J:163973
decreased hematocrit J:163973
decreased lymphocyte cell number J:163973
decreased spleen weight J:163973
decreased thymus weight J:163973
increased circulating alanine transaminase level J:163973
increased circulating aspartate transaminase level J:163973
increased hemoglobin content J:163973
increased liver weight J:163973
increased neutrophil cell number J:163973
increased physiological sensitivity to xenobiotic J:163973
increased susceptibility to weight loss J:163973
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory