Cyp1a1^tm4.1Dwn
Targeted Allele Detail

Summary

• Symbol: Cyp1a1^tm4.1Dwn
• Name: cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 4.1, Daniel W Nebert
• MGI ID: MGI:4830524
• Synonyms: Cyp1a1^mtp
• Gene: Cyp1a1 Location: Chr9:57595211-57611107 bp, + strand Genetic Position: Chr9, 31.34 cM
• Alliance: Cyp1a1^tm4.1Dwn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with a modified exon 2 in which nucleotide substitutions (CTT to AAT at codon 7 and CTC to AAC at codon 17) result in the amino acid substitutions of asparagine for leucine at positions 7 and 17 (L7N and L17N) in the SRP-binding and ER transmembrane anchor/stop transfer sequence. A floxed neo cassette inserted upstream of the modified exon was removed by cre mediated recombination. The product is predicted to undergo mitochondrial proteolysis targeting. (J:163973)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp1a1 Mutation: 35 strains or lines available

References

• Original: J:163973 Dong H, et al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Mol Pharmacol. 2009 Mar;75(3):555-67
• All: 1 reference(s)