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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cyp1a1tm4.1Dwn
targeted mutation 4.1, Daniel W Nebert
MGI:4830524
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn B6.129X1-Cyp1a1tm4.1Dwn MGI:4830530


Genotype
MGI:4830530
hm1
Allelic
Composition
Cyp1a1tm4.1Dwn/Cyp1a1tm4.1Dwn
Genetic
Background
B6.129X1-Cyp1a1tm4.1Dwn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp1a1tm4.1Dwn mutation (0 available); any Cyp1a1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• benzo[a]pyrene (BaP)-treated mice exhibit moderate toxicity (weight loss, decreased spleen and thymus weight, increased liver weight, increased serum alanine and aspartate transaminase levels, decreased hematocrit and hemoglobin, increased methemoglobin, increased neutrophils, and decreased lymphocytes) compared with similarly treated wild-type mice
• BaP-toxicity is not as severe as in similarly treated Cyp1a1tm1.1Dwn homozygotes
• benzo[a]pyrene (BaP)-treated mice exhibit an 25-fold increase in BaP serum levels compared to wild-type mice

hematopoietic system
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• benzo[a]pyrene (BaP)-treated mice exhibit an increase in methemoglobin compared with similarly treated wild-type mice
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice

liver/biliary system
• in benzo[a]pyrene (BaP)-treated mice

growth/size/body
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice

immune system
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice
• in benzo[a]pyrene (BaP)-treated mice

endocrine/exocrine glands
• in benzo[a]pyrene (BaP)-treated mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory