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Targeted Allele Detail
Symbol: Cyp1a1tm1.1Dwn
Name: cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 1.1, Daniel W Nebert
MGI ID: MGI:2182307
Synonyms: Cyp1a1(-)
Gene: Cyp1a1  Location: Chr9:57595211-57611107 bp, + strand  Genetic Position: Chr9, 31.34 cM
Alliance: Cyp1a1tm1.1Dwn page
Dioxin-induced hepatic injury in Cyp1a1tm1.1Dwn/Cyp1a1tm1.1Dwn and Cyp1a2tm1Dwn/Cyp1a2tm1Dwn mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:59398
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre recombinase RNA was injected into zygotes heterozygous for Cyp1a1tm1Dwn. A region containing a floxed HPRT minigene and the entire coding region of Cyp1a1 was excised by cre recombinase. Northern and Western blot analyses of total RNA and protein extracts obtained from animals treated with TCDD (to enhance expression levels) showed an absence of endogenous transcript and normal protein in the livers of homozygous mutant mice. (J:59398)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp1a1 Mutation:  26 strains or lines available
Original:  J:59398 Dalton TP, et al., Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem Biophys Res Commun. 2000 Jan 7;267(1):184-9
All:  25 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory