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Bmi1 Gene Detail
Summary
  • Symbol
    Bmi1
  • Name
    Bmi1 polycomb ring finger oncogene
  • Synonyms
    Bmi1, Bmi-1, Pcgf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88174
    NCBI Gene: 12151
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18681953-18691440 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88174
 protein coding gene Chr2:18681829-18691440 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025376
 protein coding gene Chr2:16391653-16402922 (+)
A/J MGP_AJ_G0025354
 protein coding gene Chr2:15730345-15741268 (+)
AKR/J MGP_AKRJ_G0025322
 protein coding gene Chr2:16247717-16259583 (+)
BALB/cJ MGP_BALBcJ_G0025349
 protein coding gene Chr2:15752670-15763409 (+)
C3H/HeJ MGP_C3HHeJ_G0025109
 protein coding gene Chr2:16177858-16185490 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025792
 protein coding gene Chr2:16807126-16820536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023207
 protein coding gene Chr2:15119888-15129427 (+)
CAST/EiJ MGP_CASTEiJ_G0024573
 protein coding gene Chr2:16140226-16154204 (+)
CBA/J MGP_CBAJ_G0025088
 protein coding gene Chr2:17563963-17577074 (+)
DBA/2J MGP_DBA2J_G0025220
 protein coding gene Chr2:15654998-15665803 (+)
FVB/NJ MGP_FVBNJ_G0025183
 protein coding gene Chr2:15451953-15461975 (+)
LP/J MGP_LPJ_G0025307
 protein coding gene Chr2:16225460-16236476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025214
 protein coding gene Chr2:17526331-17536854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025850
 protein coding gene Chr2:16203835-16213300 (+)
PWK/PhJ MGP_PWKPhJ_G0024322
 protein coding gene Chr2:15531292-15541817 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024122
 protein coding gene Chr2:16334548-16348942 (+)
WSB/EiJ MGP_WSBEiJ_G0024643
 protein coding gene Chr2:16261721-16269468 (+)



Homology
more
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMI1, BMI1 proto-oncogene, polycomb ring finger
  • Synonyms
    flvi-2/bmi-1, FLVI2/BMI1, PCGF4, RNF51
  • Links
    NCBI Gene ID: 648
    neXtProt AC: NX_P35226
    UniProt: P35226

  • Chr Location
    10p12.2; chr10:22321099-22331484 (+)  GRCh38
  • Human Ortholog
    COMMD3-BMI1, COMMD3-BMI1 readthrough
  • Synonyms
    BMI1, PCGF4, RNF51
  • Links
    NCBI Gene ID: 100532731
    neXtProt AC: NX_P35226

  • Chr Location
    chr10:22316388-22331484 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BMI1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 6 alleles in 9 genetic backgrounds
    66 phenotypes from multigenic genotypes
    162 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display severe hematopoietic defects, neurological abnormalities, posterior transformation, and infertility in both sexes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1449
  • Tissues
    378
  • cDNA Data
    142
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12151 NCBI Gene Model | MGI Sequence Detail 9488 C57BL/6J ±  kb
    transcript NM_007552 RefSeq | MGI Sequence Detail 3470 ZRU/MplStud  
    polypeptide P25916 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 157
      Genomic 6
      cDNA 143
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1588, MGD-MRK-1589, MGI:2139375
    References
    more
    • Summaries
      All 308
      Developmental Gene Expression 65
      Gene Ontology 28
      Phenotypes 162
    • Earliest
      J:11213 van Lohuizen M, et al., Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging [see comments]. Cell. 1991 May 31;65(5):737-52
    • Latest
      J:345616 Gao M, et al., Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction. Theranostics. 2024;14(4):1371-1389
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory