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Tg(Ccl5*-EGFP)RBRmutItan
Transgene Detail
Summary
Symbol: Tg(Ccl5*-EGFP)RBRmutItan
Name: transgene insertion RBRmut, Ichiro Taniuchi
MGI ID: MGI:7384517
Synonyms: Ccl5-GFP-RBRM BAC Tg
Transgene: Tg(Ccl5*-EGFP)RBRmutItan  Location: unknown  
Alliance: Tg(Ccl5*-EGFP)RBRmutItan page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(Ccl5*-EGFP)RBRmutItan expresses 13 genes
 
Mutation details: The transgene insert consists of BAC B6Ng01-015L02 where the Ccl5 coding region from start codon to stop codon (4741 bp) was replaced with the EGFP fluorescent reporter gene cDNA and mutations to inactivate two Runx recognition sequences (RRSs) within the Ccl5-RBR were created. The BAC also contains Ccl3, -4, -6 and -9, Heatr9 and the 3' end of Taf15. (J:287321)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:287321 Seo W, et al., Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity. Nat Commun. 2020 Mar 26;11(1):1562
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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03/25/2025
MGI 6.24 		The Jackson Laboratory