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Ccl3 Gene Detail
Summary
  • Symbol
    Ccl3
  • Name
    C-C motif chemokine ligand 3
  • Synonyms
    CCL3, G0S19-1, LD78alpha, macrophage inflammatory protein-1alpha, Mip1a, MIP1-(a), MIP-1alpha, MIP-1 alpha, MIP1-alpha, Scya3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98260
    NCBI Gene: 20302
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83538670-83540181 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.04 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98260
protein coding gene Chr11:83538669-83540204 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018856
protein coding gene Chr11:85011871-85013382 (-)
A/J MGP_AJ_G0018823
protein coding gene Chr11:81760395-81761906 (-)
AKR/J MGP_AKRJ_G0018793
protein coding gene Chr11:84198651-84200163 (-)
BALB/cJ MGP_BALBcJ_G0018796
protein coding gene Chr11:82177289-82178800 (-)
C3H/HeJ MGP_C3HHeJ_G0018610
protein coding gene Chr11:84260116-84261627 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019248
protein coding gene Chr11:87598549-87600060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016881
protein coding gene Chr11:78875337-78876872 (-)
CAST/EiJ MGP_CASTEiJ_G0018165
protein coding gene Chr11:84837920-84839428 (-)
CBA/J MGP_CBAJ_G0018581
protein coding gene Chr11:91368073-91369584 (-)
DBA/2J MGP_DBA2J_G0018689
protein coding gene Chr11:81358792-81360304 (-)
FVB/NJ MGP_FVBNJ_G0018678
protein coding gene Chr11:80845419-80846930 (-)
LP/J MGP_LPJ_G0018759
protein coding gene Chr11:85553479-85554990 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018705
protein coding gene Chr11:91532050-91533561 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019288
protein coding gene Chr11:84478438-84479948 (-)
PWK/PhJ MGP_PWKPhJ_G0017934
protein coding gene Chr11:82118114-82128717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017726
protein coding gene Chr11:84002580-84004086 (-)
WSB/EiJ MGP_WSBEiJ_G0018216
protein coding gene Chr11:84330538-84332049 (-)



Homology
more
  • Human Ortholog
    CCL18, C-C motif chemokine ligand 18
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL18, C-C motif chemokine ligand 18
  • Synonyms
    AMAC1, AMAC-1, CKb7, DCCK1, DC-CK1, MIP-4, PARC, SCYA18
  • Links
    NCBI Gene ID: 6362
    neXtProt AC: NX_P55774
    UniProt: P55774

  • Chr Location
    17q12; chr17:36064272-36072032 (+)  GRCh38

  • Human Ortholog
    CCL3, C-C motif chemokine ligand 3
  • Synonyms
    G0S19-1, LD78, LD78ALPHA, MIP1A, MIP-1-alpha, SCI, SCYA3
  • Links
    NCBI Gene ID: 6348
    neXtProt AC: NX_P10147
    UniProt: P10147

  • Chr Location
    17q12; chr17:36088256-36090169 (-)  GRCh38

  • Human Ortholog
    CCL3L1, C-C motif chemokine ligand 3 like 1
  • Synonyms
    464.2, D17S1718, G0S19-2, LD78, LD78BETA, LD78-beta(1-70), MIP1AP, SCYA3L, SCYA3L1
  • Links
    NCBI Gene ID: 6349
    neXtProt AC: NX_P16619
    UniProt: P16619

  • Chr Location
    17q21.1; chr17:36194869-36196758 (-)  GRCh38

  • Human Ortholog
    CCL3L3, C-C motif chemokine ligand 3 like 3
  • Synonyms
    464.2, D17S1718, G0S19-2, LD78, LD78BETA, SCYA3L, SCYA3L1
  • Links
    NCBI Gene ID: 414062
    neXtProt AC: NX_P16619
    UniProt: P16619

  • Chr Location
    17q12; chr17:36194869-36196758 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CCL3,CCL3L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene exhibit resistance to Coxsackie virus-induced myocarditis and reduced pneumonitis following infection with influenza virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000982 Ensembl Gene Model | MGI Sequence Detail 1512 C57BL/6J ±  kb
    transcript ENSMUST00000001008 Ensembl | MGI Sequence Detail 766 Not Applicable  
    polypeptide ENSMUSP00000001008 Ensembl | MGI Sequence Detail 92 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 43
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12241, MGD-MRK-14334, MGI:2144123
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 14
      Phenotypes 87
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346451 Klement L, et al., Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1alpha activation. Biochim Biophys Acta Mol Basis Dis. 2024 Jan 9;1870(3):167016

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory