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Cldn16 Gene Detail
Summary
  • Symbol
    Cldn16
  • Name
    claudin 16
  • Synonyms
    claudin-16, paracellin-1, PCLN1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148742
    NCBI Gene: 114141
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:26281885-26301515 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 18.10 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148742
 protein coding gene Chr16:26281885-26301515 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022694
 protein coding gene Chr16:24187262-24217760 (+)
A/J MGP_AJ_G0022656
 protein coding gene Chr16:23051994-23074260 (+)
AKR/J MGP_AKRJ_G0022630
 protein coding gene Chr16:23997832-24017287 (+)
BALB/cJ MGP_BALBcJ_G0022661
 protein coding gene Chr16:23263900-23283369 (+)
C3H/HeJ MGP_C3HHeJ_G0022425
 protein coding gene Chr16:24097449-24117102 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023110
 protein coding gene Chr16:24724807-24751517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020628
 protein coding gene Chr16:23625504-23645645 (+)
CAST/EiJ MGP_CASTEiJ_G0021954
 protein coding gene Chr16:24135423-24156280 (+)
CBA/J MGP_CBAJ_G0022396
 protein coding gene Chr16:25785136-25805604 (+)
DBA/2J MGP_DBA2J_G0022528
 protein coding gene Chr16:23003382-23023423 (+)
FVB/NJ MGP_FVBNJ_G0022504
 protein coding gene Chr16:22990364-23010536 (+)
LP/J MGP_LPJ_G0022596
 protein coding gene Chr16:23973062-24003440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022523
 protein coding gene Chr16:25190713-25215590 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023122
 protein coding gene Chr16:23957197-23980120 (+)
PWK/PhJ MGP_PWKPhJ_G0021693
 protein coding gene Chr16:23288273-23308486 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021524
 protein coding gene Chr16:23710346-23729995 (+)
WSB/EiJ MGP_WSBEiJ_G0021998
 protein coding gene Chr16:23879779-23905028 (+)



Homology
more
  • Human Ortholog
    CLDN16, claudin 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN16, claudin 16
  • Synonyms
    HOMG3, PCLN1
  • Links
    NCBI Gene ID: 10686
    neXtProt AC: NX_Q9Y5I7
    UniProt: Q9Y5I7

  • Chr Location
    3q28; chr3:190290361-190412138 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cldn16 mouse models; 2 with human CLDN16 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display an age-dependent progressive phenotype that includes hypercalciuria and hypomagnesemia, significantly elevated serum parathyroid hormone and calcitriol (1,25(OH)2D3) levels, and a significantly lower urinary pH but no nephrocalcinosis or renal failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    10
  • cDNA Data
    5
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114141 NCBI Gene Model | MGI Sequence Detail 19631 C57BL/6J ±  kb
    transcript NM_053241 RefSeq | MGI Sequence Detail 1173 C57BL/6  
    polypeptide Q925N4 UniProt | EBI | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 5
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:73057 Weber S, et al., Primary gene structure and expression studies of rodent paracellin-1. J Am Soc Nephrol. 2001 Dec;12(12):2664-72
    • Latest
      J:313345 Higashi AY, et al., Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep. 2021 Nov 4;11(1):21642
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory