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Atg7 Gene Detail
Summary
  • Symbol
    Atg7
  • Name
    autophagy related 7
  • Synonyms
    1810013K23Rik, Apg7l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921494
    NCBI Gene: 74244
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:114620075-114837565 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.05 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4841 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921494
 protein coding gene Chr6:114620058-114837575 (+)
129S1/SvImJ ENSMUSG00200023998
 protein coding gene Chr6:111835437-112052904 (+)
A/J ENSMUSG00195015919
 protein coding gene Chr6:111225856-111443406 (+)
AKR/J ENSMUSG00220031442
 protein coding gene Chr6:110142002-110356989 (+)
BALB/cJ ENSMUSG00180002213
 protein coding gene Chr6:111591562-111809111 (+)
C3H/HeJ ENSMUSG00175031744
 protein coding gene Chr6:65623884-65838880 (-)
C57BL/6NJ ENSMUSG00215017284
 protein coding gene Chr6:111578673-111796220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028745
 protein coding gene Chr6:109754538-109967611 (+)
CAST/EiJ ENSTCUG00005028270
 protein coding gene Chr6:111443988-111659974 (+)
CBA/J ENSMUSG00210020268
 protein coding gene Chr6:111399132-111614046 (+)
DBA/2J ENSMUSG00185045993
 protein coding gene Chr6:112033915-112251407 (+)
FVB/NJ ENSMUSG00205014205
 protein coding gene Chr6:110461928-110679390 (+)
JF1/MsJ ENSUMUG00000015507
 protein coding gene Chr6:110694063-110906610 (+)
LP/J ENSMUSG00230042083
 protein coding gene Chr6:113238326-113455800 (+)
NOD/ShiLtJ ENSMUSG00190016394
 protein coding gene Chr6:110988168-111205646 (+)
NZO/HlLtJ ENSMUSG00225046691
 protein coding gene Chr6:115094016-115311516 (+)
PWK/PhJ ENSLUMG00010024778
 protein coding gene Chr6:109994324-110208617 (+)
SPRET/EiJ ENSMSPG00010035769
 protein coding gene Chr6:112791771-113003521 (+)
WSB/EiJ ENSIUOG00005022855
 protein coding gene Chr6:111724230-111941746 (+)



Homology
more
  • Human Ortholog
    ATG7, autophagy related 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG7, autophagy related 7
  • Synonyms
    APG7L, APG7-LIKE, GSA7, SCAR31
  • Links
    NCBI Gene ID: 10533
    UniProt: O95352

  • Chr Location
    3p25.3; chr3:11272309-11576353 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Atg7 mouse models; 1 with human ATG7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    101 phenotypes from 3 alleles in 14 genetic backgrounds
    48 phenotypes from multigenic genotypes
    444 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this gene causes impairment of constitutive and starvation-induced autophagy resulting in defective protein degradation. Homozygous null mice die within 1 day of birth and have decreased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    134
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    652
  • Tissues
    34
  • cDNA Data
    79
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74244 NCBI Gene Model | MGI Sequence Detail 217491 C57BL/6J ±  kb
    transcript NM_001253717 RefSeq | MGI Sequence Detail 3872 C57BL/6  
    polypeptide Q9D906 UniProt | EBI | MGI Sequence Detail 698 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000004419 ubiquitin-like modifier-activating enzyme ATG7
      (term hierarchy)
    • InterPro Domains
      IPR045886 ThiF/MoeB/HesA family
      IPR000594 THIF-type NAD/FAD binding fold
      IPR035985 Ubiquitin-activating enzyme-like
      IPR006285 Ubiquitin-like modifier-activating enzyme Atg7
      IPR032197 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal
      IPR042522 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1
      IPR042523 Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2
    • GlyGen
      Q9D906 3 sites, 4 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 79
      Primer pair 3

      Microarray probesets 6
    References
    more
    • Summaries
      All 579
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 36
      Phenotypes 444
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:391717 Huang X, et al., Liver-originated selective autophagy of BTD by alectinib underlies concurrent hepatotoxicity and dermatotoxicity. Autophagy. 2026 Sep;22(9):2424-2449
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory