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Tlr2 Gene Detail
Summary
  • Symbol
    Tlr2
  • Name
    toll-like receptor 2
  • Synonyms
    Ly105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346060
    NCBI Gene: 24088
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:83743579-83749045 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346060
 protein coding gene Chr3:83743579-83749074 (-)
129S1/SvImJ ENSMUSG00200018865
 protein coding gene Chr3:80581709-80587205 (-)
A/J ENSMUSG00195011534
 protein coding gene Chr3:80615548-80621043 (-)
AKR/J ENSMUSG00220001363
 protein coding gene Chr3:80560336-80565831 (-)
BALB/cJ ENSMUSG00180001861
 protein coding gene Chr3:80733025-80738520 (-)
C3H/HeJ ENSMUSG00175007118
 protein coding gene Chr3:80542566-80548061 (-)
C57BL/6NJ ENSMUSG00215045880
 protein coding gene Chr3:80984344-80989839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025109
 protein coding gene Chr3:76605003-76610527 (-)
CAST/EiJ ENSTCUG00005001580
 protein coding gene Chr3:80086224-80091705 (-)
CBA/J ENSMUSG00210025322
 protein coding gene Chr3:80686786-80692281 (-)
DBA/2J ENSMUSG00185012726
 protein coding gene Chr3:80817692-80823187 (-)
FVB/NJ ENSMUSG00205006348
 protein coding gene Chr3:79611232-79616728 (-)
JF1/MsJ ENSUMUG00000001512
 protein coding gene Chr3:80379638-80385229 (-)
LP/J ENSMUSG00230031716
 protein coding gene Chr3:82802265-82807761 (-)
NOD/ShiLtJ ENSMUSG00190031818
 protein coding gene Chr3:81067697-81073192 (-)
NZO/HlLtJ ENSMUSG00225006849
 protein coding gene Chr3:85543102-85548598 (-)
PWK/PhJ ENSLUMG00010006062
 protein coding gene Chr3:80435903-80441490 (-)
SPRET/EiJ ENSMSPG00010047978
 protein coding gene Chr3:81250908-81255783 (-)
WSB/EiJ ENSIUOG00005049307
 protein coding gene Chr3:81043814-81049309 (-)



Homology
more
  • Human Ortholog
    TLR2, toll like receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR2, toll like receptor 2
  • Synonyms
    CD282, TIL4
  • Links
    NCBI Gene ID: 7097
    UniProt: O60603

  • Chr Location
    4q31.3; chr4:153684050-153710637 (+)  GRCh38
Human Diseases
more
  • Diseases
    25 with human TLR2 associations

Human Disease Mouse Models
      
IDs
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 View 1 "NOT" model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    121 phenotypes from 4 alleles in 13 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1186 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections. Mice homozygous for a knock-out allele also exhibit disruption in circadian active and inactive state consolidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    145
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    113
  • cDNA Data
    23
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24088 NCBI Gene Model | MGI Sequence Detail 5467 C57BL/6J ±  kb
    transcript NM_011905 RefSeq | MGI Sequence Detail 2874 C57BL/6  
    polypeptide Q9QUN7 UniProt | EBI | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 23
      Primer pair 6
      Antibodies 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 1740
      Developmental Gene Expression 20
      Diseases 2
      Gene Ontology 34
      Phenotypes 1186
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:389754 Zhao FR, et al., Gut microbe-derived short-chain fatty acids regulate alphavirus arthritis and macrophage activation in mice. J Clin Invest. 2026 Jul 15;136(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory