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Ncoa1 Gene Detail
Summary
  • Symbol
    Ncoa1
  • Name
    nuclear receptor coactivator 1
  • Synonyms
    bHLHe74, KAT13A, SRC1, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276523
    NCBI Gene: 17977
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4297362-4527182 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 2.05 cM, cytoband A2-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276523
protein coding gene Chr12:4297362-4569452 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019567
protein coding gene Chr12:1118640-1236529 (-)
A/J MGP_AJ_G0019534
protein coding gene Chr12:1131577-1362814 (-)
AKR/J MGP_AKRJ_G0019504
protein coding gene Chr12:1290468-1532120 (-)
BALB/cJ MGP_BALBcJ_G0019509
protein coding gene Chr12:1150796-1383710 (-)
C3H/HeJ MGP_C3HHeJ_G0019315
protein coding gene Chr12:1074906-1312711 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019958
protein coding gene Chr12:1145666-1390962 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017583
protein coding gene Chr12:1033945-1268264 (-)
CAST/EiJ MGP_CASTEiJ_G0018870
protein coding gene Chr12:1143902-1390956 (-)
CBA/J MGP_CBAJ_G0019286
protein coding gene Chr12:1414062-1690060 (-)
DBA/2J MGP_DBA2J_G0019399
protein coding gene Chr12:1067444-1296816 (-)
FVB/NJ MGP_FVBNJ_G0019389
protein coding gene Chr12:1089959-1312582 (-)
LP/J MGP_LPJ_G0019470
protein coding gene Chr12:1136338-1375323 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019423
protein coding gene Chr12:1199172-1466393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019997
protein coding gene Chr12:1075144-1321511 (-)
PWK/PhJ MGP_PWKPhJ_G0018636
protein coding gene Chr12:1094744-1342485 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018427
protein coding gene Chr12:1137552-1234785 (-)
WSB/EiJ MGP_WSBEiJ_G0018921
protein coding gene Chr12:1097072-1207057 (-)



Homology
more
  • Human Ortholog
    NCOA1, nuclear receptor coactivator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA1, nuclear receptor coactivator 1
  • Synonyms
    bHLHe42, bHLHe74, F-SRC-1, KAT13A, RIP160, SRC1
  • Links
    NCBI Gene ID: 8648
    neXtProt AC: NX_Q15788
    UniProt: Q15788

  • Chr Location
    2p23.3; chr2:24491254-24770702 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Ncoa1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 5 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show osteopenia, increased serum sex hormone levels, altered bone remodeling and skeletal responses to sex hormones, and obesity. Homozygotes for another null allele show thyroid and steroid hormone resistance, delayed Purkinje cell development, and behavioral deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020647 Ensembl Gene Model | MGI Sequence Detail 229821 C57BL/6J ±  kb
    transcript ENSMUST00000220434 Ensembl | MGI Sequence Detail 4756 Not Applicable  
    polypeptide ENSMUSP00000151358 Ensembl | MGI Sequence Detail 1447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 1
      cDNA 106
      Primer pair 4

      Microarray probesets 5
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 23
      Diseases 2
      Gene Ontology 20
      Phenotypes 68
    • Earliest
      J:32922 Kamei Y, et al., A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996 May 3;85(3):403-14
    • Latest
      J:324775 Guo P, et al., Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene. 2022 May;41(20):2846-2859

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory