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Hgf Gene Detail
Summary
  • Symbol
    Hgf
  • Name
    hepatocyte growth factor
  • Synonyms
    C230052L06Rik, HGF/SF, NK1, NK2, scatter factor, SF/HGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96079
    NCBI Gene: 15234
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:16758493-16825150 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 7.07 cM, cytoband A2-A3
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1863 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96079
 protein coding gene Chr5:16758493-16827448 (+)
129S1/SvImJ ENSMUSG00200009714
 protein coding gene Chr5:12400081-12468955 (+)
A/J ENSMUSG00195038966
 protein coding gene Chr5:11857689-11926580 (+)
AKR/J ENSMUSG00220036181
 protein coding gene Chr5:11814320-11883162 (+)
BALB/cJ ENSMUSG00180020384
 protein coding gene Chr5:11714859-11783751 (+)
C3H/HeJ ENSMUSG00175026064
 protein coding gene Chr5:13666842-13735739 (+)
C57BL/6NJ ENSMUSG00215012271
 protein coding gene Chr5:12277603-12346508 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026973
 protein coding gene Chr5:11840023-11909452 (+)
CAST/EiJ ENSTCUG00005003022
 protein coding gene Chr5:12055153-12123090 (+)
CBA/J ENSMUSG00210004589
 protein coding gene Chr5:12706221-12775118 (+)
DBA/2J ENSMUSG00185016721
 protein coding gene Chr5:14211228-14280104 (+)
FVB/NJ ENSMUSG00205026611
 protein coding gene Chr5:11437469-11506364 (+)
JF1/MsJ ENSUMUG00000001393
 protein coding gene Chr5:18847452-18914902 (+)
LP/J ENSMUSG00230002383
 protein coding gene Chr5:18721027-18789896 (+)
NOD/ShiLtJ ENSMUSG00190004864
 protein coding gene Chr5:11738022-11806919 (+)
NZO/HlLtJ ENSMUSG00225008995
 protein coding gene Chr5:24083601-24152497 (+)
PWK/PhJ ENSLUMG00010033091
 protein coding gene Chr5:11889977-11957449 (+)
SPRET/EiJ ENSMSPG00010027289
 protein coding gene Chr5:12689424-12756970 (+)
WSB/EiJ ENSIUOG00005030442
 protein coding gene Chr5:14554730-14623706 (+)



Homology
more
  • Human Ortholog
    HGF, hepatocyte growth factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HGF, hepatocyte growth factor
  • Synonyms
    DFNB39, F-TCF, HGFB, HPTA, SF
  • Links
    NCBI Gene ID: 3082
    UniProt: P14210

  • Chr Location
    7q21.11; chr7:81699010-81770438 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Hgf mouse models; 16 with human HGF associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 12 alleles in 16 genetic backgrounds
    31 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1294
  • Tissues
    379
  • cDNA Data
    38
  • Literature Summary
    79
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028864 Ensembl Gene Model | MGI Sequence Detail 66658 C57BL/6J ±  kb
    transcript ENSMUST00000199581 Ensembl | MGI Sequence Detail 3468 Not Applicable  
    polypeptide ENSMUSP00000143424 Ensembl | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      Genomic 10
      cDNA 40
      Primer pair 21
      Other 8
      Antibodies 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10704, MGI:2443459
    References
    more
    • Summaries
      All 288
      Developmental Gene Expression 79
      Diseases 6
      Gene Ontology 16
      Phenotypes 76
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391705 Nakano Y, et al., CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice. iScience. 2026 Sep 18;29(9):117341
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory