Myt1l MGI Mouse Gene Detail - MGI:1100511 - myelin transcription factor 1-like

Symbol

Myt1l
Name

myelin transcription factor 1-like
Synonyms

2900046C06Rik, 2900093J19Rik, C630034G21Rik, mKIAA1106, Nztf1, Pmng1, Png-1

Feature Type

protein coding gene
IDs

MGI:1100511
NCBI Gene: 17933
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr12:29578383-29973212 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 11.86 cM
Mapping Data

4 experiments

SNPs within 2kb

4261 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100511	protein coding gene	Chr12:29578375-29973215 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019648	protein coding gene	Chr12:27397749-27811854 (+)
A/J	MGP_AJ_G0019615	protein coding gene	Chr12:26636534-27043741 (+)
AKR/J	MGP_AKRJ_G0019586	protein coding gene	Chr12:27531567-27935725 (+)
BALB/cJ	MGP_BALBcJ_G0019592	protein coding gene	Chr12:26892383-27296587 (+)
C3H/HeJ	MGP_C3HHeJ_G0019396	protein coding gene	Chr12:27378602-27783897 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020039	protein coding gene	Chr12:28281269-28689784 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017664	protein coding gene	Chr12:25991288-26384321 (+)
CAST/EiJ	MGP_CASTEiJ_G0018951	protein coding gene	Chr12:22361090-22776238 (+)
CBA/J	MGP_CBAJ_G0019367	protein coding gene	Chr12:29252480-29659433 (+)
DBA/2J	MGP_DBA2J_G0019481	protein coding gene	Chr12:26488324-26887674 (+)
FVB/NJ	MGP_FVBNJ_G0019472	protein coding gene	Chr12:26299752-26701784 (+)
LP/J	MGP_LPJ_G0019551	protein coding gene	Chr12:27486488-27902250 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019507	protein coding gene	Chr12:28846218-29257042 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020079	protein coding gene	Chr12:27051360-27459566 (+)
PWK/PhJ	MGP_PWKPhJ_G0018718	protein coding gene	Chr12:21210270-21611269 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018506	protein coding gene	Chr12:21645739-22048278 (+)
WSB/EiJ	MGP_WSBEiJ_G0019002	protein coding gene	Chr12:27264942-27670380 (+)

Human Ortholog

MYT1L, myelin transcription factor 1 like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYT1L, myelin transcription factor 1 like
Synonyms

MRD39, myT1-L, NZF1, ZC2H2C2, ZC2HC4B
Links

HGNC:7623

NCBI Gene ID: 23040

neXtProt AC: NX_Q9UL68

UniProt: Q9UL68
Chr Location

2p25.3; chr2:1789113-2331664 (-) GRCh38

MGI Vertebrate Homology

Myt1l stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYT1L
Gene Tree

Myt1l

Diseases

1 with Myt1l mouse models; 1 with human MYT1L associations

Human Disease

Mouse Models

autosomal dominant intellectual developmental disorder 39

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

35 phenotypes from 3 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show neonatal lethality. Heterozygous pups show altered communication while adults become overweight, show hyperactivity due to impaired habituation, reduced motor performance and anxiety, enhanced startle reflex and nest building, and impaired contextual conditioning behavior.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1069
Tissues

294
cDNA Data

29
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYT1L

Xenbase myt1l

ZFIN myt1la, myt1lb

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All Sequences

172
RefSeq

102
UniProt

4
CCDS

CCDS49041.1, CCDS49042.1

Ensembl

ENSMUSG00000061911 (Evidence)
NCBI Gene

17933

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061911	Ensembl Gene Model \| MGI Sequence Detail	394830	C57BL/6J	± kb
transcript	ENSMUST00000049784	Ensembl \| MGI Sequence Detail	7202	Not Applicable
polypeptide	ENSMUSP00000058264	Ensembl \| MGI Sequence Detail	1187	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010893 myelin transcription factor 1-like protein

(term hierarchy)
InterPro Domains

IPR013681 Myelin transcription factor 1

IPR002515 Zinc finger, C2H2C-type

IPR036060 Zinc finger, C2H2C-type superfamily

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All nucleic 37

cDNA 32

Primer pair 5

Microarray probesets 8

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MGD-MRK-36441, MGI:107864, MGI:1920146, MGI:1920316, MGI:2443117, MGI:891972

Summaries

All 65

Developmental Gene Expression 28

Diseases 2

Gene Ontology 7

Phenotypes 10
Earliest

J:39021 Jiang Y, et al., A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996 May 3;271(18):10723-30
Latest

J:336866 Puelles L, et al., The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)

TSS for Myt1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113059	Chr12:29578381-29578467 (+)	41 bp
Tssr113060	Chr12:29578470-29578497 (+)	101 bp
Tssr113061	Chr12:29578526-29578548 (+)	154 bp
Tssr113062	Chr12:29578638-29578648 (+)	260 bp
Tssr113063	Chr12:29583279-29583290 (+)	4,902 bp
Tssr113064	Chr12:29583291-29583314 (+)	4,920 bp
Tssr113065	Chr12:29583350-29583363 (+)	4,974 bp
Tssr113066	Chr12:29583427-29583445 (+)	5,053 bp
Tssr113067	Chr12:29583450-29583466 (+)	5,075 bp
Tssr113068	Chr12:29583476-29583491 (+)	5,101 bp
Tssr113069	Chr12:29584560-29584640 (+)	6,217 bp
Tssr113070	Chr12:29584715-29584724 (+)	6,337 bp
Tssr113071	Chr12:29584846-29584912 (+)	6,496 bp
Tssr113072	Chr12:29585180-29585204 (+)	6,809 bp
Tssr113073	Chr12:29585208-29585236 (+)	6,839 bp
Tssr113074	Chr12:29616748-29616759 (+)	38,371 bp
Tssr113075	Chr12:29774421-29774429 (+)	196,042 bp
Tssr113076	Chr12:29782906-29782909 (+)	204,525 bp
Tssr113077	Chr12:29833624-29833641 (+)	255,250 bp
Tssr113078	Chr12:29833844-29833864 (+)	255,471 bp
Tssr113080	Chr12:29861567-29861582 (+)	283,192 bp
Tssr113081	Chr12:29890206-29890249 (+)	311,845 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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