95 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adam17tm1.2Bbl/Adam17tm1.2Bbl Il17atm1Yiw/Il17atm1Yiw Sox9tm3(cre)Crm/Sox9+ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL	dermatitis	J:229771
Adam17tm1.2Bbl/Adam17tm1.2Bbl Il23atm1Dnax/Il23atm1Dnax Sox9tm3(cre)Crm/Sox9+ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL	dermatitis	J:229771
Adam17tm1.2Bbl/Adam17tm1.2Bbl Sox9tm3(cre)Crm/Sox9+ B6.129(SJL)-Sox9tm3(cre)Crm Adam17tm1.2Bbl	abnormal circulating chemokine level	J:229771
	abnormal epidermal layer morphology	J:229771
	abnormal skin morphology	J:229771
	dermatitis	J:229771
	dry skin	J:229771
	impaired skin barrier function	J:229771
	increased IgE level	J:229771
	increased pruritus	J:229771
	increased T-helper 1 cell number	J:229771
	increased T-helper 2 cell number	J:229771
	increased T-helper 17 cell number	J:229771
Adam17tm1.2Bbl/Adam17tm1.2Bbl Sox9tm3(cre)Crm/Sox9+ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal bone marrow cavity morphology	J:144795
	abnormal bone remodeling	J:144795
	abnormal hair growth	J:144795
	abnormal long bone epiphyseal plate proliferative zone	J:144795
	abnormal long bone hypertrophic chondrocyte zone	J:144795
	abnormal skin condition	J:144795
	abnormal spleen morphology	J:144795
	decreased B cell number	J:144795
	decreased body weight	J:144795
	decreased bone mass	J:144795
	decreased compact bone thickness	J:144795
	decreased hematocrit	J:144795
	decreased length of long bones	J:144795
	decreased lymphocyte cell number	J:144795
	decreased T cell number	J:144795
	decreased trabecular bone thickness	J:144795
	early eyelid opening	J:144795
	enlarged spleen	J:144795
	extramedullary hematopoiesis	J:144795
	female infertility	J:144795
	increased bone marrow cell number	J:144795
	increased circulating interleukin-17 level	J:144795
	increased hemoglobin content	J:144795
	increased interleukin-17 secretion	J:144795
	increased leukocyte cell number	J:144795
	increased macrophage cell number	J:144795
	increased neutrophil cell number	J:144795
	increased spleen red pulp amount	J:144795
	osteoporosis	J:144795
	postnatal growth retardation	J:144795
	premature death	J:144795
	reduced male fertility	J:144795
	short femur	J:144795
	thrombocytosis	J:144795
Axin2tm1Wbm/Axin2+ Tg(Wt1-Sox9)92Asc/? involves: 129 * C57BL/6	abnormal sex gland morphology	J:133933
Col2a1tm1(SOX9)Crm/Col2a1+ Sox9tm1Crm/Sox9+ involves: 129S4/SvJae	abnormal skeleton development	J:90567
	decreased body size	J:90567
	neonatal lethality, incomplete penetrance	J:90567
Ctnnb1tm1.1Smoc/Ctnnb1tm1.1Smoc Sox9em1(cre/ERT2)Tchn/Sox9+ involves: C57BL/6	increased incidence of tumors by chemical induction	J:322311
Egfrtm1Dwt/Egfrtm1Dwt Sox9tm3(cre)Crm/Sox9+ involves: 129S6/SvEvTac * 129S7/SvEvBrd	abnormal epidermal layer morphology	J:229771
	abnormal skin morphology	J:229771
	dermatitis	J:229771
	impaired skin barrier function	J:229771
	increased IgE level	J:229771
	increased T-helper 1 cell number	J:229771
	increased T-helper 2 cell number	J:229771
	increased T-helper 17 cell number	J:229771
Gnai2tm2.1Lbi/Gnai2+ Gnai3tm1Lbi/Gnai3tm1Lbi Sox9tm3(cre)Crm/Sox9+ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6	rib fusion	J:193170
Gnai2tm2.1Lbi/Gnai2tm2.1Lbi Gnai3tm1Lbi/Gnai3tm1Lbi Sox9tm3(cre)Crm/Sox9+ involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6	lumbar vertebral fusion	J:193170
	rib fusion	J:193170
Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+ Sox9tm3(cre)Crm/Sox9+ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	abnormal ankle joint morphology	J:158676
	abnormal foot pad morphology	J:158676
	abnormal skeleton morphology	J:158676
	abnormal tendon morphology	J:158676
	decreased skeletal muscle mass	J:158676
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+ Sox9tm3(cre)Crm/Sox9+ Tg(tetO-Vegfa)1Kesh/0 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal blood vessel morphology	J:147285
	increased vascular endothelial cell number	J:147285
Gt(ROSA)26Sortm6Dym/? Smotm2Amc/Smotm2Amc Sox9tm3(cre)Crm/Sox9+ involves: 129S7/SvEvBrd * 129X1/SvJ	abnormal temporomandibular joint morphology	J:153743
	small mandibular condyloid process	J:153743
Hoxa13Hd/Hoxa13+ Tg(Prrx1-Sox9,-lacZ)1Haak/0 involves: C57BL/6 * DBA/2 * MYA/Hu	abnormal hallux morphology	J:121946
	abnormal phalanx morphology	J:121946
	polydactyly	J:121946
Lmx1btm1Rjo/Lmx1btm1Zfc Sox9tm3(cre)Crm/Sox9+ involves: 129S7/SvEvBrd	abnormal metacarpal bone morphology	J:158676
	normal skeleton phenotype	J:158676
Shhtm1Chg/Shhtm1Chg Tg(Prrx1-Sox9,-lacZ)1Haak/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal limb bud morphology	J:121946
Sox8tm1Weg/Sox8+ Sox9tm2Crm/Sox9tm2Crm Tg(Nr5a1-cre)5Asc/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	abnormal primary sex determination	J:89368
	absent Leydig cells	J:89368
	cryptorchism	J:89368
	decreased Sertoli cell number	J:89368
	sex reversal	J:89368
Sox8tm1Weg/Sox8tm1Weg Sox9tm2.1Crm/Sox9+ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J	abnormal primary sex determination	J:89368
	abnormal seminiferous tubule morphology	J:89368
	sex reversal	J:89368
Sox8tm1Weg/Sox8tm1Weg Sox9tm2Crm/Sox9tm2Crm Tg(Nr5a1-cre)5Asc/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	abnormal primary sex determination	J:89368
	absent Leydig cells	J:89368
	cryptorchism	J:89368
	decreased Sertoli cell number	J:89368
	sex reversal	J:89368
Sox9em1(cre/ERT2)Smoc/Sox9+ Tnfsf18em1Pwan/Tnfsf18em1Pwan involves: C57BL/6J	abnormal response to injury	J:346395
	abnormal T cell activation	J:346395
	decreased CD8-positive, alpha-beta T cell number	J:346395
	decreased circulating alanine transaminase level	J:346395
	decreased circulating aspartate transaminase level	J:346395
	decreased hepatoblast number	J:346395
	decreased inflammatory response	J:346395
Sox9em1(cre/ERT2)Tchn/Sox9+ Stk26tm2.1Zzh/Stk26tm2.1Zzh involves: 129P2/OlaHsd * C57BL/6	abnormal enterocyte proliferation	J:322311
	decreased incidence of tumors by chemical induction	J:322311
Sox9em1(cre/ERT2)Tchn/Sox9+ Stk26tm2.1Zzh/Stk26tm2.1Zzh involves: C57BL/6 * SJL	increased incidence of tumors by chemical induction	J:322311
Sox9tm2Crm/Sox9+ Rr80em1Jwsk/Rr80+ E2f1Tg(Wnt1-cre)2Sor/E2f1+ involves: 129S7/SvEvBrd * C3H * C57BL/6J * FVB/NJ	abnormal mandible morphology	J:306395
	mandibular condyloid process hypoplasia	J:306395
	postnatal growth retardation	J:306395
	short mandible	J:306395
Sox9tm3(cre)Crm/Sox9+ Sp7tm1Crm/Sp7tm2Crm involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal axial skeleton morphology	J:102495
	abnormal bone mineralization	J:102495
	abnormal bone ossification	J:102495
	abnormal limb bone morphology	J:102495
	abnormal osteoblast differentiation	J:102495
	abnormal rib morphology	J:102495
	abnormal skeleton development	J:102495
	abnormal trabecular bone morphology	J:102495
	abnormal vertebrae morphology	J:102495
	neonatal lethality, complete penetrance	J:102495
Sox10tm1Ngan/Sox10+ Sox9tm2Crm/Sox9+ Tg(Rr141-cre)1Ksec/0 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	dilated cochlea	J:332093
Sox10tm1Ngan/Sox10+ Sox9tm1.1Ksec/Sox9+ Tg(Rr141-cre)1Ksec/0 involves: 129S/SvEv * C57BL/6 * CBA	dilated cochlea	J:332093