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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox9
SRY (sex determining region Y)-box 9
MGI:98371
95 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Adam17tm1.2Bbl/\Adam17tm1.2Bbl
\Il17atm1Yiw/\Il17atm1Yiw
\Sox9tm3(cre)Crm/\Sox9+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL 		dermatitis J:229771
\Adam17tm1.2Bbl/\Adam17tm1.2Bbl
\Il23atm1Dnax/\Il23atm1Dnax
\Sox9tm3(cre)Crm/\Sox9+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL 		dermatitis J:229771
\Adam17tm1.2Bbl/\Adam17tm1.2Bbl
\Sox9tm3(cre)Crm/\Sox9+
B6.129(SJL)-Sox9tm3(cre)Crm Adam17tm1.2Bbl 		abnormal circulating chemokine level J:229771
abnormal epidermal layer morphology J:229771
abnormal skin morphology J:229771
dermatitis J:229771
dry skin J:229771
impaired skin barrier function J:229771
increased IgE level J:229771
increased pruritus J:229771
increased T-helper 1 cell number J:229771
increased T-helper 2 cell number J:229771
increased T-helper 17 cell number J:229771
\Adam17tm1.2Bbl/\Adam17tm1.2Bbl
\Sox9tm3(cre)Crm/\Sox9+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow cavity morphology J:144795
abnormal bone remodeling J:144795
abnormal hair growth J:144795
abnormal long bone epiphyseal plate proliferative zone J:144795
abnormal long bone hypertrophic chondrocyte zone J:144795
abnormal skin condition J:144795
abnormal spleen morphology J:144795
decreased B cell number J:144795
decreased body weight J:144795
decreased bone mass J:144795
decreased compact bone thickness J:144795
decreased hematocrit J:144795
decreased length of long bones J:144795
decreased lymphocyte cell number J:144795
decreased T cell number J:144795
decreased trabecular bone thickness J:144795
early eyelid opening J:144795
enlarged spleen J:144795
extramedullary hematopoiesis J:144795
female infertility J:144795
increased bone marrow cell number J:144795
increased circulating interleukin-17 level J:144795
increased hemoglobin content J:144795
increased interleukin-17 secretion J:144795
increased leukocyte cell number J:144795
increased macrophage cell number J:144795
increased neutrophil cell number J:144795
increased spleen red pulp amount J:144795
osteoporosis J:144795
postnatal growth retardation J:144795
premature death J:144795
reduced male fertility J:144795
short femur J:144795
thrombocytosis J:144795
\Axin2tm1Wbm/\Axin2+
\Tg(Wt1-Sox9)92Asc/?
involves: 129 * C57BL/6 		abnormal sex gland morphology J:133933
\Col2a1tm1(SOX9)Crm/\Col2a1+
\Sox9tm1Crm/\Sox9+
involves: 129S4/SvJae 		abnormal skeleton development J:90567
decreased body size J:90567
neonatal lethality, incomplete penetrance J:90567
\Ctnnb1tm1.1Smoc/\Ctnnb1tm1.1Smoc
\Sox9em1(cre/ERT2)Tchn/\Sox9+
involves: C57BL/6 		increased incidence of tumors by chemical induction J:322311
\Egfrtm1Dwt/\Egfrtm1Dwt
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal epidermal layer morphology J:229771
abnormal skin morphology J:229771
dermatitis J:229771
impaired skin barrier function J:229771
increased IgE level J:229771
increased T-helper 1 cell number J:229771
increased T-helper 2 cell number J:229771
increased T-helper 17 cell number J:229771
\Gnai2tm2.1Lbi/\Gnai2+
\Gnai3tm1Lbi/\Gnai3tm1Lbi
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 		rib fusion J:193170
\Gnai2tm2.1Lbi/\Gnai2tm2.1Lbi
\Gnai3tm1Lbi/\Gnai3tm1Lbi
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 		lumbar vertebral fusion J:193170
rib fusion J:193170
\Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/\Gt(ROSA)26Sor+
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal ankle joint morphology J:158676
abnormal foot pad morphology J:158676
abnormal skeleton morphology J:158676
abnormal tendon morphology J:158676
decreased skeletal muscle mass J:158676
\Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/\Gt(ROSA)26Sor+
\Sox9tm3(cre)Crm/\Sox9+
\Tg(tetO-Vegfa)1Kesh/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal blood vessel morphology J:147285
increased vascular endothelial cell number J:147285
\Gt(ROSA)26Sortm6Dym/?
\Smotm2Amc/\Smotm2Amc
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal temporomandibular joint morphology J:153743
small mandibular condyloid process J:153743
\Hoxa13Hd/\Hoxa13+
\Tg(Prrx1-Sox9,-lacZ)1Haak/0
involves: C57BL/6 * DBA/2 * MYA/Hu 		abnormal hallux morphology J:121946
abnormal phalanx morphology J:121946
polydactyly J:121946
\Lmx1btm1Rjo/\Lmx1btm1Zfc
\Sox9tm3(cre)Crm/\Sox9+
involves: 129S7/SvEvBrd 		abnormal metacarpal bone morphology J:158676
normal skeleton phenotype J:158676
\Shhtm1Chg/\Shhtm1Chg
\Tg(Prrx1-Sox9,-lacZ)1Haak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal limb bud morphology J:121946
\Sox8tm1Weg/\Sox8+
\Sox9tm2Crm/\Sox9tm2Crm
\Tg(Nr5a1-cre)5Asc/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA 		abnormal primary sex determination J:89368
absent Leydig cells J:89368
cryptorchism J:89368
decreased Sertoli cell number J:89368
sex reversal J:89368
\Sox8tm1Weg/\Sox8tm1Weg
\Sox9tm2.1Crm/\Sox9+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6J 		abnormal primary sex determination J:89368
abnormal seminiferous tubule morphology J:89368
sex reversal J:89368
\Sox8tm1Weg/\Sox8tm1Weg
\Sox9tm2Crm/\Sox9tm2Crm
\Tg(Nr5a1-cre)5Asc/?
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA 		abnormal primary sex determination J:89368
absent Leydig cells J:89368
cryptorchism J:89368
decreased Sertoli cell number J:89368
sex reversal J:89368
\Sox9em1(cre/ERT2)Smoc/\Sox9+
\Tnfsf18em1Pwan/\Tnfsf18em1Pwan
involves: C57BL/6J 		abnormal response to injury J:346395
abnormal T cell activation J:346395
decreased CD8-positive, alpha-beta T cell number J:346395
decreased circulating alanine transaminase level J:346395
decreased circulating aspartate transaminase level J:346395
decreased hepatoblast number J:346395
decreased inflammatory response J:346395
\Sox9em1(cre/ERT2)Tchn/\Sox9+
\Stk26tm2.1Zzh/\Stk26tm2.1Zzh
involves: 129P2/OlaHsd * C57BL/6 		abnormal enterocyte proliferation J:322311
decreased incidence of tumors by chemical induction J:322311
\Sox9em1(cre/ERT2)Tchn/\Sox9+
\Stk26tm2.1Zzh/\Stk26tm2.1Zzh
involves: C57BL/6 * SJL 		increased incidence of tumors by chemical induction J:322311
\Sox9tm2Crm/\Sox9+
\Rr80em1Jwsk/\Rr80+
\E2f1Tg(Wnt1-cre)2Sor/\E2f1+
involves: 129S7/SvEvBrd * C3H * C57BL/6J * FVB/NJ 		abnormal mandible morphology J:306395
mandibular condyloid process hypoplasia J:306395
postnatal growth retardation J:306395
short mandible J:306395
\Sox9tm3(cre)Crm/\Sox9+
\Sp7tm1Crm/\Sp7tm2Crm
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal axial skeleton morphology J:102495
abnormal bone mineralization J:102495
abnormal bone ossification J:102495
abnormal limb bone morphology J:102495
abnormal osteoblast differentiation J:102495
abnormal rib morphology J:102495
abnormal skeleton development J:102495
abnormal trabecular bone morphology J:102495
abnormal vertebrae morphology J:102495
neonatal lethality, complete penetrance J:102495
\Sox10tm1Ngan/\Sox10+
\Sox9tm2Crm/\Sox9+
\Tg(Rr141-cre)1Ksec/0
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA 		dilated cochlea J:332093
\Sox10tm1Ngan/\Sox10+
\Sox9tm1.1Ksec/\Sox9+
\Tg(Rr141-cre)1Ksec/0
involves: 129S/SvEv * C57BL/6 * CBA 		dilated cochlea J:332093
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03/25/2025
MGI 6.24 		The Jackson Laboratory