Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Randy L Johnson
• MGI ID: MGI:4441172
• Synonyms: ROSA26^Lmx1b
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158676
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lmx1b (MGI:1100513)

• Mutation details: A CAG promoter, floxed STOP cassette, mouse Lmx1b cDNA, IRES sequence, and human placental alkaline phoshatase cDNA were inserted into the locus. (J:158676)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:158676 Li Y, et al., Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning. Development. 2010 Apr;137(7):1181-8
• All: 6 reference(s)