All Phenotypes Gt(ROSA)26Sor<tm1(CAG-Lmx1b,ALPP)Rjo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺ Sox9^tm3(cre)Crm/Sox9⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:4441200
cn2	Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J	MGI:4441201

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with ventral cartilaginous protrusions unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

muscle

decreased skeletal muscle mass ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

limbs/digits/tail

abnormal foot pad morphology ( J:158676 )

• mice exhibit hair on the ventral skin of the paw unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Lmx1b,ALPP)Rjo} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

muscle

decreased skeletal muscle mass ( J:158676 )

• mice exhibit loss of muscle tissue in the ventral limb unlike wild-type mice

abnormal tendon morphology ( J:158676 )

• tendon elements exhibit a partial ventral to dorsal conversion with partial conversion of ventral tendon to a dorsal morphology unlike in wild-type mice

• the lateral flexor digitorium profundus tendon is absent unlike in wild-type mice

• the flexor digitorium sublimus is flattened unlike in wild-type mice

limbs/digits/tail

abnormal foot pad morphology ( J:158676 )

• mice exhibit hair on the ventral skin of the paw unlike in wild-type mice

abnormal ankle joint morphology ( J:158676 )

• the ventral flexure at the ankle is absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23