Il17a^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Il17a^tm1Yiw
• Name: interleukin 17A; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:2388010
• Synonyms: IL-17-, Il17a^-, IL-17A KO, IL-17-GFP, IL-17KO
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79127
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a cassette containing an EGFP gene followed by a floxed neomycin resistance gene. Transcript was undetected by Northern blot analysis of stimulated splenic T cells derived from homozygous mutant mice. The absence of protein in T cell supernatent was determined by ELISA. (J:79127)

Expression

In Mice Carrying this Mutation:	104036 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 22 strains or lines available

References

• Original: J:79127 Nakae S, et al., Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses. Immunity. 2002 Sep;17(3):375-387
• All: 313 reference(s)