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Allele Symbol Allele Name Allele ID |
Il17atm1Yiw targeted mutation 1, Yoichiro Iwakura MGI:2388010 |
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| Summary |
16 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased survival rate in response to i.v C. albicans NBRC1385 infection
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• decreased survival rate in response to i.v C. albicans NBRC1385 infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the skin of IMQ-treated mice
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• in the skin of IMQ-treated mice
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• there is no difference in onset or severity of experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein peptide (MOG) compared to controls
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• in the skin of IMQ-treated mice
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• in the skin of IMQ-treated mice
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• mice are protected from IMQ (Aldara)-induced psoriasis with decreased ear swelling and numbers of neutrophils and gamma-delta T cells in the skin compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced specific IgE after intraperitoneal immunization
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• reduced specific IgG1 after intraperitoneal immunization
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• reduced Il4 and Il5 levels after initial immunizations
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• proliferative respose of mesenteric Langerhans cells to antigen reduced 5 days after initial immunization
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• airway hypersensitivity response reduced
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• reduced Il4 and Il5 levels after initial immunizations
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• reduced specific IgE after intraperitoneal immunization
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• reduced specific IgG1 after intraperitoneal immunization
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium than in controls
• mild hypertrophy of the colon and spleen occur after infection with C. rodentium
• C. rodentium infection leads to slightly more severe histopathology of the colon than wild-type controls, and significantly increases crypt length
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced specific IgG1 and IgG3 levels 1 week after contact hypersensitivity tests
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• reduced contact hypersensitivity
• delayed hypersensitivity response about 80% normal
• less cell infiltration
• reduced T-cell proliferative response
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• reduced production of IFN gamma
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• reduced specific IgG1 and IgG3 levels 1 week after contact hypersensitivity tests
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop eczematous dermatitis
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• mice develop eczematous dermatitis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased survival rate in response to i.v C. albicans NBRC1385 infection
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• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
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• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age
• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment
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• decreased survival rate in response to i.v C. albicans NBRC1385 infection
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• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
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• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes
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• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 91.7% of mutants are alive after 12 months of age; this is a 61.1% improvement of survival rates compared to Fcgr2b nulls heterozygous for Il17a
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• 91.7% of mutants are alive after 12 months of age, indicating some loss before one year of age
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• increase in numbers of double negative T cells in the kidneys
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• develop spontaneous germinal centers (to a similar level that is seen in Fcgr2b nulls heterozygous for Il17a)
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• mutants are much less susceptible to lupus pathology compared to single Fcgr2b homozygotes or Fcgr2b nulls heterozygous for Il17a
• mutants exhibit reduced inflammatory cell infiltration and glomerulonephritis in kidneys compared to Fcgr2b nulls heterozygous for Il17a
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• increase in numbers of double negative T cells in the kidneys
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• develop spontaneous germinal centers (to a similar level that is seen in Fcgr2b nulls heterozygous for Il17a)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 35.7% of mutants are alive after 12 months of age
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• about 35.7% of mutants are alive after 12 months of age
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• develop spontaneous germinal centers
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• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions
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• develop spontaneous germinal centers
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• infiltrating neutrophils and monocytic cells in the kidney, extending into interstitial regions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
|
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
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• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
|
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
|
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• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age
• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
• S. aureus is readily culturable from mucosal surfaces of the nose and mouth but is not culturable from controls
• mice have the same resistance to systemic infection of S. aureus as determined by survival curves and the amount of colony forming units in kidney homegenates after inoculation with S. aureus
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
|
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• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
|
• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
|
• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls
|
|
• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls
|
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• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced incidence of arthritis
• severity of arthritis not reduced
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• reduced incidence of arthritis
• severity of arthritis not reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• arthritis suppressed
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• arthritis suppressed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium
• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium
• C. rodentium infection leads to more severe histopathology of the colon than controls, and significantly increases crypt length
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show decreased saliva flow, comparable to single Tg(CD2-Rorc)#Staka hemizygotes
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• mice show decreased saliva flow, comparable to single Tg(CD2-Rorc)#Staka hemizygotes
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• mice show decreased saliva flow, comparable to single Tg(CD2-Rorc)#Staka hemizygotes
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• mice spontaneously develop sialadenitis
• focus score of inflammatory lesions in the salivary glands is comparable to single Tg(CD2-Rorc)#Staka hemizygotes
• presence of CD4+ T and B cells in the salivary glands
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• concanavalin-induced liver damage is similar to that in Il22tm2Flv single homozygous mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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