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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox1
SRY (sex determining region Y)-box 1
MGI:98357
39 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Dicer1tm1Bdh/\Dicer1tm1Bdh
\Sox1tm1(cre)Take/\Sox1+
involves: 129 * C57BL/6NCrlj * CBA/JNCrlj 		perinatal lethality, complete penetrance J:244791
short rostral-caudal axis J:244791
\Enpp2tm1.1Vart/\Enpp2tm1.1Vart
\Sox1tm2Vep/\Sox1+
involves: C57BL/6 		abnormal neural tube morphology J:159118
kinked neural tube J:159118
open neural tube J:159118
\Eomestm1Rob/\Eomestm1Rob
\Sox1tm1(cre)Take/0
involves: 129S/SvEv * C57BL/6 * CBA 		abnormal axon guidance J:138764
abnormal dentate gyrus morphology J:138764
abnormal neuron apoptosis J:138764
abnormal neuronal precursor proliferation J:138764
abnormal olfactory bulb morphology J:138764
absent anterior commissure J:138764
decreased brain size J:138764
decreased grip strength J:138764
increased aggression towards humans J:138764
increased aggression towards mice J:138764
increased exploration in new environment J:138764
small olfactory bulb J:138764
thin cerebral cortex J:138764
\Fkrptm1Scbr/\Fkrptm1Scbr
\Sox1tm1(cre)Take/\Sox1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		centrally nucleated skeletal muscle fibers J:207119
decreased body weight J:207119
dystrophic muscle J:207119
hydrocephaly J:207119
muscle degeneration J:207119
myositis J:207119
postnatal lethality, incomplete penetrance J:207119
\Fkrptm1Scbr/\Fkrptm1Scbr
\Sox1tm1(cre)Take/\Sox1+
\Tg(CAG-LARGE)126Fmu/0
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj 		abnormal muscle morphology J:207119
abnormal muscle physiology J:207119
abnormal reflex J:207119
calcified muscle J:207119
centrally nucleated skeletal muscle fibers J:207119
dystrophic muscle J:207119
myositis J:207119
premature death J:207119
skeletal muscle fibrosis J:207119
skeletal muscle hypertrophy J:207119
\Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/\Gt(ROSA)26Sor+
\Sox1tm1(cre)Take/\Sox1+
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal cardiovascular system phenotype J:203163
normal embryo phenotype J:203163
normal hematopoietic system phenotype J:203163
normal mortality/aging J:203163
\Sox1tm1Vep/\Sox1tm1Vep
\Sox2tm1Vep/\Sox2+
involves: 129S/SvEv 		abnormal olfactory cortex morphology J:99610
\Sox1tm1Vep/\Sox1tm2Vep
\Sox2tm1Vep/\Sox2+
involves: 129S/SvEv 		abnormal olfactory cortex morphology J:99610
microphthalmia J:99610
premature death J:99610
seizures J:99610
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory