Kdm6a^tm1.1Homy
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.1Homy
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.1, Hiroaki Honda
• MGI ID: MGI:6828650
• Synonyms: Utx^flox
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.1Homy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303803
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 11 and 12 were flanked by loxP sites. An FRT-flanked neomycin resistance gene was inserted downstream of the second loxP site and was removed via Flp-mediated recombination. (J:303803)

Expression

In Mice Carrying this Mutation:

26 assay results

Tumor Data

List all tumor models in MMHCdb carrying Kdm6a^tm1.1Homy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 38 strains or lines available

References

• Original: J:303803 Sera Y, et al., UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. Blood. 2021 Feb 18;137(7):908-922
• All: 3 reference(s)