Pold1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pold1
polymerase (DNA directed), delta 1, catalytic subunit
MGI:97741

26 phenotypes from 8 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pold1^tm1.1Bdp/Pold1^tm1.1Bdp B6.129-Pold1^tm1.1Bdp	increased intestinal adenocarcinoma incidence	J:153684
	increased intestinal adenoma incidence	J:153684
	increased lung tumor incidence	J:153684
	increased lymphoma incidence	J:153684
	increased skin tumor incidence	J:153684
	increased T cell derived lymphoma incidence	J:153684
	premature death	J:153684
Pold1^tm1.1Uchi/Pold1^tm1.1Uchi C57BL/6-Pold1^tm1.1Uchi	normal embryo phenotype	J:144992
	enlarged thymus	J:144992
	increased tumor incidence	J:144992
	premature death	J:144992
Pold1^tm1Bdp/Pold1^tm1Bdp involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased lung adenocarcinoma incidence	J:100685
	increased lymphoma incidence	J:80306, J:100685
	increased sarcoma incidence	J:100685
	increased skin tumor incidence	J:80306
	increased squamous cell carcinoma incidence	J:100685
	increased T cell derived lymphoma incidence	J:100685
	increased tumor incidence	J:80306, J:100685
	premature death	J:80306
Pold1^tm1Loeb/Pold1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	cardiomyopathy	J:129046
	premature death	J:129046
Pold1^tm1Loeb/Pold1^tm1Loeb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:129046
Pold1^tm1Uchi/Pold1^tm1.1Uchi C57BL/6-Pold1^tm1Uchi/Pold1^tm1.1Uchi	normal embryo phenotype	J:144992
	enlarged thymus	J:144992
	increased tumor incidence	J:144992
	premature death	J:144992
Pold1^tm1Uchi/Pold1^tm1Uchi C57BL/6-Pold1^tm1Uchi	abnormal trophoblast layer morphology	J:144992
	absent inner cell mass proliferation	J:144992
	embryonic lethality between implantation and somite formation, complete penetrance	J:144992
	inner cell mass degeneration	J:144992
Pold1^tm2Loeb/Pold1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	increased tumor incidence	J:129046
	premature death	J:129046
Pold1^tm2Loeb/Pold1^tm2Loeb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	embryonic lethality between somite formation and embryo turning, complete penetrance	J:129046
Pold1^tyrn/Pold1^{tm1b(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	embryonic lethality between implantation and somite formation, complete penetrance	J:327432
Pold1^tyrn/Pold1^tyrn C57BL/6J-Pold1^tyrn	abnormal embryonic tissue morphology	J:327432
	decreased cell proliferation	J:327432
	decreased embryo size	J:327432
	normal embryo phenotype	J:327432
	increased embryonic tissue cell apoptosis	J:327432
Pold1^tyrn/Pold1^tyrn Tg(Hhex-EGFP)#Rbe/0 involves: C57BL/6 * C57BL/6J * CBA/J	abnormal allantois morphology	J:327432
	abnormal primitive streak elongation	J:327432
	normal embryo phenotype	J:327432

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23