Pold1^tyrn
Chemically induced Allele Detail

Summary

• Symbol: Pold1^tyrn
• Name: polymerase (DNA directed), delta 1, catalytic subunit; tiny siren
• MGI ID: MGI:7467225
• Gene: Pold1 Location: Chr7:44182168-44198239 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Pold1^tyrn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a c.2815G>T mutation, changing aspartic acid codon 939 (GAC) (p.D939Y) in exon 23 to tyrosine (TAC). The mutated residue is located in the thumb domain of the C-terminal DNA polymerase domain of the encoded peptide. (J:327432)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pold1 Mutation: 62 strains or lines available

References

• Original: J:327432 Chen T, et al., A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 2022 Aug 15;11(8):bio059307
• All: 1 reference(s)