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Pold1 Gene Detail
Summary
  • Symbol
    Pold1
  • Name
    polymerase (DNA directed), delta 1, catalytic subunit
  • Synonyms
    125kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:97741
    NCBI Gene: 18971
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44182168-44198239 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    453 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97741
 protein coding gene Chr7:44182168-44198273 (-)
129S1/SvImJ ENSMUSG00200024484
 protein coding gene Chr7:31775157-31791023 (-)
A/J ENSMUSG00195046675
 protein coding gene Chr7:35802811-35818912 (-)
AKR/J ENSMUSG00220047017
 protein coding gene Chr7:30108087-30123954 (-)
BALB/cJ ENSMUSG00180035155
 protein coding gene Chr7:32678195-32694298 (-)
C3H/HeJ ENSMUSG00175034665
 protein coding gene Chr7:33211109-33226973 (-)
C57BL/6NJ ENSMUSG00215042920
 protein coding gene Chr7:32471925-32488024 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029665
 protein coding gene Chr7:46475302-46490985 (-)
CAST/EiJ ENSTCUG00005045622
 protein coding gene Chr7:36189094-36204754 (-)
CBA/J ENSMUSG00210046899
 protein coding gene Chr7:33582490-33598352 (-)
DBA/2J ENSMUSG00185042425
 protein coding gene Chr7:37448201-37463823 (-)
FVB/NJ ENSMUSG00205034164
 protein coding gene Chr7:33127671-33143543 (-)
JF1/MsJ ENSUMUG00000013918
 protein coding gene Chr7:41935411-41951033 (-)
LP/J ENSMUSG00230049998
 protein coding gene Chr7:42877626-42893725 (-)
NOD/ShiLtJ ENSMUSG00190024916
 protein coding gene Chr7:33455471-33471336 (-)
NZO/HlLtJ ENSMUSG00225015748
 protein coding gene Chr7:41088412-41104514 (-)
PWK/PhJ ENSLUMG00010037701
 protein coding gene Chr7:32411484-32427099 (-)
SPRET/EiJ ENSMSPG00010037223
 protein coding gene Chr7:32193035-32208821 (-)
WSB/EiJ ENSIUOG00005022145
 protein coding gene Chr7:34000142-34016246 (-)



Homology
more
  • Human Ortholog
    POLD1, DNA polymerase delta 1, catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLD1, DNA polymerase delta 1, catalytic subunit
  • Synonyms
    CDC2, CRCS10, IMD120, MDPL, POLD
  • Links
    NCBI Gene ID: 5424
    UniProt: P28340

  • Chr Location
    19q13.33; chr19:50384204-50418018 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POLD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 8 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have an elevated mutation rate as well as an increased incidence of tumors. Median age for these mice is around 10 months.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    121
  • cDNA Data
    118
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18971 NCBI Gene Model | MGI Sequence Detail 16072 C57BL/6J ±  kb
    transcript NM_011131 RefSeq | MGI Sequence Detail 3428 ZRU/MplStud  
    polypeptide P52431 UniProt | EBI | MGI Sequence Detail 1105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012963 DNA polymerase delta catalytic subunit
      (term hierarchy)
    • EC
      2.7.7.7, 3.1.11.-
    • InterPro Domains
      IPR025687 C4-type zinc-finger of DNA polymerase delta
      IPR006172 DNA-directed DNA polymerase, family B
      IPR017964 DNA-directed DNA polymerase, family B, conserved site
      IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
      IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
      IPR056435 DNA polymerase delta/zeta catalytic subunit, N-terminal domain
      IPR042087 DNA polymerase family B, thumb domain
      IPR023211 DNA polymerase, palm domain superfamily
      IPR050240 DNA polymerase type-B
      IPR043502 DNA/RNA polymerase superfamily
      IPR012337 Ribonuclease H-like superfamily
      IPR036397 Ribonuclease H superfamily
    • GlyGen
      P52431 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 1
      cDNA 118
      Primer pair 2
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13579
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:16041 Cullmann G, et al., Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes. Gene. 1993 Dec 8;134(2):191-200
    • Latest
      J:372024 Roichman A, et al., Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models. Cancer Res. 2025 Sep 2;85(17):3335-3347
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory