Prkaca Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Prkaca^tm1Gsm/Prkaca⁺ Prkacb^tm1Gsm/Prkacb^tm1Gsm involves: 129X1/SvJ * C57BL/6	abnormal dorsal root ganglion morphology	J:76765
	abnormal embryonic neuroepithelium morphology	J:76765
	abnormal neural tube morphology	J:76765
	abnormal neuron specification	J:76765
	abnormal spine curvature	J:76765
	abnormal vertebral arch morphology	J:76765
	abnormal vertebral column morphology	J:76765
	disorganized dorsal root ganglion	J:76765
	increased neural tube apoptosis	J:76765
	postnatal lethality	J:76765
	spina bifida	J:76765
Prkaca^tm1Gsm/Prkaca⁺ Prkar1a^tm1.1Lsk/Prkar1a⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal bone mineralization	J:160299
	abnormal compact bone morphology	J:160299
	abnormal periosteum morphology	J:160299
	decreased bone mineral density	J:160299
	increased osteochondroma incidence	J:160299
	increased osteosarcoma incidence	J:160299
	increased skeletal tumor incidence	J:160299, J:166728
	normal neoplasm	J:160299
Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb⁺ involves: 129X1/SvJ * C57BL/6	abnormal dorsal root ganglion morphology	J:76765
	abnormal embryonic neuroepithelium morphology	J:76765
	abnormal neural tube morphology	J:76765
	abnormal neuron specification	J:76765
	abnormal spine curvature	J:76765
	abnormal vertebral arch morphology	J:76765
	abnormal vertebral column morphology	J:76765
	disorganized dorsal root ganglion	J:76765
	embryonic lethality, complete penetrance	J:76765
	exencephaly	J:76765
	spina bifida	J:76765
Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkacb^tm1Gsm/Prkacb^tm1Gsm involves: 129X1/SvJ * C57BL/6	embryonic lethality between somite formation and embryo turning, complete penetrance	J:76765
Prkaca^tm1Gsm/Prkaca^tm1Gsm Prkar1a^tm1Gsm/Prkar1a^tm1Gsm involves: 129X1/SvJ * C57BL/6	pericardial edema	J:78010
Prkaca^tm4.1Gsm/Prkaca^tm4.1Gsm involves: C57BL/6	abnormal sperm motility	J:163375

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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