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Prkacatm1Gsm
Targeted Allele Detail
Summary
Symbol: Prkacatm1Gsm
Name: protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2181021
Synonyms: Calpha-
Gene: Prkaca  Location: Chr8:84699622-84723072 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Alliance: Prkacatm1Gsm page
Neural tube defects leading to spina bifida in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77110
Parent Cell Line:  REK3 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6-8 were replaced with a neomycin resistance cassette via homologous recombination. The knockout allele was confirmed via the absence of protein product in brain of homozygous mutant animals as determined by Western blot analysis. (J:77110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaca Mutation:  22 strains or lines available
References
Original:  J:77110 Skalhegg BS, et al., Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol. 2002 Mar;16(3):630-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory