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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pbx1
pre B cell leukemia homeobox 1
MGI:97495
116 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cd19tm1(cre)Cgn/\Cd19+
\Pbx1tm2Mlc/\Pbx1tm2Mlc
involves: 129P2/OlaHsd * 129S6/SvEvTac 		no abnormal phenotype detected J:132963
\Nkx2-5tm2(cre)Rph/\Nkx2-5+
\Pbx1tm1.1Koss/\Pbx1tm1.1Koss
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal spleen morphology J:184521
spleen hypoplasia J:184521
\Pbx1em1Dunw/\Pbx1em1Dunw
C57BL/6J-Pbx1em1Dunw 		abnormal primary sex determination J:320934
abnormal stomach position or orientation J:320934
adrenal gland hypoplasia J:320934
cleft secondary palate J:320934
decreased brain size J:320934
ectopic thymus J:320934
esophageal atresia J:320934
eyelids open at birth J:320934
hunched posture J:320934
larynx stenosis J:320934
liver hypoplasia J:320934
pelvic kidney J:320934
persistent truncus arteriosus J:320934
pulmonary hypoplasia J:320934
spleen hypoplasia J:320934
stomach hypoplasia J:320934
subcutaneous edema J:320934
thymus hypoplasia J:320934
trachea occlusion J:320934
umbilical hernia J:320934
ventricular septal defect J:320934
\Pbx1tm1.1Febe/\Pbx1+
involves: C57BL/6 		abnormal response/metabolism to endogenous compounds J:129552
decreased adrenal gland zona fasciculata size J:129552
small adrenal glands J:129552
\Pbx1tm1.1Febe/\Pbx1tm1.1Febe
involves: C57BL/6 		abnormal embryonic growth/weight/body size J:129552
abnormal limb morphology J:129552
abnormal vasculogenesis J:129552
hunched posture J:129552
pallor J:129552
skin edema J:129552
\Pbx1tm1.1Koss/\Pbx1tm1.1Koss
\Tg(WT1-cre)AG11Dbdr/0
involves: 129P2/OlaHsd * C57BL/6 		spleen hypoplasia J:184521
\Pbx1tm1.1Koss/\Pbx1tm1.2Koss
\Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		abnormal deltoid tuberosity morphology J:184521
abnormal humerus morphology J:184521
abnormal rib morphology J:184521
abnormal scapula morphology J:184521
absent spleen J:184521
rib fusion J:184521
scapular bone hypoplasia J:184521
short ribs J:184521
\Pbx1tm1Koss/\Pbx1tm1Koss
\Nkx2-5tm2(cre)Rph/\Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal spleen mesenchyme morphology J:184521
abnormal spleen morphology J:184521
spleen hypoplasia J:184521
\Pbx1tm1Mlc/\Pbx1+
involves: 129S6/SvEvTac * C57BL/6 		abnormal pancreatic islet morphology J:75811
decreased body size J:70684
decreased insulin secretion J:75811
impaired glucose tolerance J:75811
increased insulin sensitivity J:75811
\Pbx1tm1Mlc/\Pbx1tm1Mlc
involves: 129S6/SvEvTac 		edema J:178316
palatal shelf hypoplasia J:178316
small snout J:178316
\Pbx1tm1Mlc/\Pbx1tm1Mlc
involves: 129S6/SvEvTac * C57BL/6 		abnormal axial skeleton morphology J:71996
abnormal clavicle morphology J:71996
abnormal craniofacial bone morphology J:71996
abnormal developmental patterning J:71996
abnormal dorsal-ventral axis patterning J:71996
abnormal embryonic growth/weight/body size J:71996
abnormal embryonic tissue morphology J:71996
abnormal gonad rudiment morphology J:87270
abnormal hyoid bone lesser horn morphology J:71996
abnormal kidney cortex morphology J:82126
abnormal kidney medulla morphology J:82126
abnormal left-right axis symmetry of the somites J:71996
abnormal limb bone morphology J:71996
abnormal limb bud morphology J:71996
abnormal malleus morphology J:71996
abnormal metanephric mesenchyme morphology J:82126
abnormal metanephros morphology J:82126
abnormal middle ear ossicle morphology J:71996
abnormal nephrogenic mesenchyme morphogenesis J:82126
abnormal nephrogenic zone morphology J:82126
abnormal outer ear morphology J:71996
abnormal pelvic girdle bone morphology J:71996
abnormal proximal-distal axis patterning J:71996
abnormal scapula morphology J:71996
abnormal second pharyngeal arch morphology J:71996
abnormal styloid process morphology J:71996
abnormal ureteric bud elongation J:82126
absent adrenal gland J:87270
absent common myeloid progenitor cells J:70684
absent oval window J:71996
absent pancreatic islets J:75811
absent spleen J:70684, J:71996
absent stapes J:71996
anemia J:70684
decreased chondrocyte proliferation J:71996
decreased hematocrit J:70684
decreased nephron number J:82126
decreased renal glomerulus number J:82126
delayed kidney development J:82126
diaphragmatic hernia J:182007
ectopic kidney J:71996, J:82126
ectopic thymus J:71996
exocrine pancreas hypoplasia J:75811
impaired branching involved in ureteric bud morphogenesis J:82126
impaired hematopoiesis J:70684
lethality throughout fetal growth and development, complete penetrance J:70684
liver hypoplasia J:71996
low mean erythrocyte cell number J:70684
outer ear hypoplasia J:71996
pallor J:71996
premature chondrocyte differentiation J:71996
pulmonary hypoplasia J:71996
renal hypoplasia J:82126
short styloid process J:71996
single kidney J:82126
skin edema J:70684
small kidney J:82126
stomach hypoplasia J:71996
\Pbx1tm1Mlc/\Pbx1tm2.1Mlc
involves: 129S6/SvEvTac 		abnormal liver development J:132963
abnormal lymph node primary follicle morphology J:132963
decreased CD4-positive, alpha-beta T cell number J:132963
decreased CD8-positive, alpha-beta T cell number J:132963
decreased mature B cell number J:132963
lethality throughout fetal growth and development, complete penetrance J:132963
\Pbx1tm1Mlc/\Pbx1tm3.1Mlc
\Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal common lymphocyte progenitor cell morphology J:149799
abnormal definitive hematopoiesis J:149799
abnormal hematopoietic stem cell morphology J:149799
decreased hematopoietic stem cell number J:149799
\Pbx1tm1Mlc/\Pbx1tm3.1Mlc
\Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal common lymphocyte progenitor cell morphology J:149799
abnormal definitive hematopoiesis J:149799
abnormal hematopoietic stem cell morphology J:149799
abnormal spleen morphology J:149799
abnormal thymus morphology J:149799
decreased B cell number J:149799
decreased bone marrow cell number J:149799
decreased common myeloid progenitor cell number J:149799
decreased double-negative T cell number J:149799
decreased hematopoietic stem cell number J:149799
decreased pre-B cell number J:149799
decreased pro-B cell number J:149799
decreased T cell number J:149799
small spleen J:149799
small thymus J:149799
spleen hypoplasia J:149799
thymus hypoplasia J:149799
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory