Pbx1^tm3.1Mlc
Targeted Allele Detail

Summary

• Symbol: Pbx1^tm3.1Mlc
• Name: pre B cell leukemia homeobox 1; targeted mutation 3.1, Michael L Cleary
• MGI ID: MGI:4352849
• Synonyms: Pbx1^f
• Gene: Pbx1 Location: Chr1:167946933-168259839 bp, - strand Genetic Position: Chr1, 75.95 cM
• Alliance: Pbx1^tm3.1Mlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149799
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and an frt flanked selection cassette were inserted downstream of exon 3 via homologous recombination. The selection cassette was then removed by Flp mediated recombination leaving behind a single frt site. (J:149799)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pbx1 Mutation: 40 strains or lines available

References

• Original: J:149799 Ficara F, et al., Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell. 2008 May 8;2(5):484-96
• All: 7 reference(s)