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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nkx2-3
NK2 homeobox 3
MGI:97348
58 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nkx2-3tm1Hha/Nkx2-3tm1Hha
involves: 129S4/SvJae
abnormal leukocyte migration J:62129
abnormal marginal zone B cell morphology J:62129
abnormal mesenteric lymph node morphology J:62129
abnormal metallophilic macrophage morphology J:62129
abnormal Peyer's patch follicle morphology J:62129
abnormal spleen marginal sinus morphology J:62129
abnormal spleen marginal zone macrophage morphology J:62129
abnormal spleen morphology J:62129
abnormal spleen periarteriolar lymphoid sheath morphology J:62129
absent marginal zone B cells J:62129
absent spleen marginal zone J:62129
decreased B cell number J:62129
decreased lymphocyte cell number J:62129
decreased Peyer's patch number J:62129
decreased spleen weight J:62129
decreased spleen white pulp amount J:62129
decreased T cell number J:62129
intermingled spleen red and white pulp J:62129
small Peyer's patches J:62129
small spleen J:62129
Nkx2-3tm1Hha/Nkx2-3tm1Hha
involves: 129S4/SvJae * C57BL/6
abnormal blood vessel morphology J:54198
abnormal cell proliferation J:54198
abnormal crypts of Lieberkuhn morphology J:54198
abnormal ileum morphology J:54198
abnormal intestinal epithelium morphology J:54198
abnormal intestine morphology J:54198
abnormal jejunum morphology J:54198
abnormal small intestine morphology J:54198
abnormal spleen primary B follicle morphology J:54198
abnormal splenic cell ratio J:54198
absent spleen J:54198
absent spleen marginal zone J:54198
cachexia J:54198
decreased spleen white pulp amount J:54198
postnatal growth retardation J:54198
postnatal lethality, incomplete penetrance J:54198
small spleen J:54198
Nkx2-3tm1Rph/Nkx2-3tm1Rph
involves: 129S1/Sv * C57BL/6
abnormal duodenum morphology J:64018
abnormal gut-associated lymphoid tissue morphology J:64018
abnormal intestinal mucosa morphology J:64018
abnormal intestinal peristalsis J:64018
abnormal intestine morphology J:64018
abnormal jejunum crypts of Lieberkuhn morphology J:64018
abnormal jejunum morphology J:64018
abnormal leukocyte migration J:64018
abnormal mesenteric lymph node morphology J:64018
abnormal metallophilic macrophage morphology J:64018
abnormal molar cusp morphology J:80726
abnormal oropharynx morphology J:80726
abnormal small intestinal villus morphology J:64018
abnormal small intestine morphology J:64018
abnormal spleen B cell follicle morphology J:64018
abnormal spleen periarteriolar lymphoid sheath morphology J:64018
abnormal spleen red pulp morphology J:64018
abnormal sublingual gland morphology J:80726
abnormal tooth development J:80726
absent spleen J:64018
absent spleen marginal zone J:64018
decreased CD4-positive, alpha-beta T cell number J:64018
decreased circulating triglyceride level J:64018
decreased molar number J:80726
decreased Peyer's patch number J:64018
decreased plasma cell number J:64018
delayed intestine development J:64018
diarrhea J:64018
failure of tooth eruption J:80726
increased enterocyte cell number J:64018
increased leukocyte cell number J:64018
postnatal lethality, incomplete penetrance J:64018
small cecum J:64018
small Peyer's patches J:64018
small spleen J:64018
spleen atrophy J:64018
steatorrhea J:64018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory