Nkx2-3tm1Hha
Targeted Allele Detail
|
Symbol: |
Nkx2-3tm1Hha |
Name: |
NK2 homeobox 3; targeted mutation 1, Hans-Henning Arnold |
MGI ID: |
MGI:2386680 |
Synonyms: |
Nkx2.6- |
Gene: |
Nkx2-3 Location: Chr19:43600764-43604331 bp, + strand Genetic Position: Chr19, 36.67 cM
|
Alliance: |
Nkx2-3tm1Hha page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:54198
|
Parent Cell Line: |
J1 (ES Cell)
|
Strain of Origin: |
129S4/SvJae
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: The entire coding region of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of RNA from the duodenum, jejunum, and colon of homozygous mutant animals did not detect gene expression. In situ hybridization of E9.5 homozygous mutant embryos also failed to detect gene transcripts.
(J:54198)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Nkx2-3 Mutation: |
14 strains or lines available
|
|
Original: |
J:54198 Pabst O, et al., Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development. 1999 May;126(10):2215-25 |
All: |
9 reference(s) |
|