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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myb
myeloblastosis oncogene
MGI:97249
79 phenotypes from 11 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mybboo/Mybboo
involves: C57BL/6 		abnormal B cell differentiation J:167270
abnormal common lymphocyte progenitor cell morphology J:167270
abnormal definitive hematopoiesis J:167270
abnormal embryonic erythropoiesis J:167270
abnormal erythrocyte morphology J:167270
abnormal erythropoiesis J:167270
abnormal leukocyte morphology J:167270
abnormal megakaryocyte morphology J:167270
abnormal spleen morphology J:167270
anemia J:167270
decreased neutrophil cell number J:167270
decreased spleen white pulp amount J:167270
enlarged spleen J:167270
increased hematopoietic stem cell number J:167270
increased megakaryocyte cell number J:167270
increased nucleated erythrocyte cell number J:167270
increased number of Howell-Jolly bodies J:167270
increased spleen red pulp amount J:167270
polychromatophilia J:167270
reticulocytosis J:167270
thrombocytosis J:167270
MybM303V/MybM303V
involves: 129S1/SvlmJ * C57BL/6 		abnormal megakaryocyte differentiation J:96507
abnormal platelet shape J:96507
absent common myeloid progenitor cells J:96507
anemia J:96507
arrested B cell differentiation J:96507
arrested T cell differentiation J:96507
decreased B cell number J:96507
decreased eosinophil cell number J:96507
decreased erythrocyte cell number J:96507
decreased single-positive T cell number J:96507
decreased thymocyte number J:96507
increased bone marrow cell number J:96507
increased hematopoietic stem cell number J:96507
macrocytosis J:96507
thrombocytosis J:96507
Mybtm1.1Cgn/Myb+
involves: 129P2/OlaHsd * C57BL/6 		arrested B cell differentiation J:127234
decreased B-1 B cell number J:127234
decreased mature B cell number J:127234
decreased pre-B cell number J:127234
Mybtm1.1Cgn/Mybtm1.1Cgn
involves: 129P2/OlaHsd * C57BL/6 		anemia J:91122
lethality throughout fetal growth and development, complete penetrance J:91122
Mybtm1.1Jof/Mybtm1.1Jof
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:85344
Mybtm1b(KOMP)Wtsi/Myb+
C57BL/6N-Mybtm1b(KOMP)Wtsi/Ucd 		abnormal heart morphology J:211773
anophthalmia J:211773
enlarged heart J:211773
hemorrhage J:211773
microcephaly J:211773
microphthalmia J:211773
polydactyly J:211773
spina bifida J:211773
syndactyly J:211773
Mybtm1b(KOMP)Wtsi/Mybtm1b(KOMP)Wtsi
C57BL/6N-Mybtm1b(KOMP)Wtsi/Ucd 		anophthalmia J:211773
hemorrhage J:211773
microcephaly J:211773
microphthalmia J:211773
pallor J:211773
polydactyly J:211773
preweaning lethality, incomplete penetrance J:211773
spina bifida J:211773
syndactyly J:211773
Mybtm1Cgn/Mybtm1.1Cgn
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:91122
Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:91122
decreased double-positive T cell number J:91122
thymus hypoplasia J:91122
Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		arrested T cell differentiation J:91122
decreased CD4-positive, alpha-beta T cell number J:91122
decreased CD8-positive, alpha-beta T cell number J:91122
decreased double-negative T cell number J:91122
decreased double-positive T cell number J:91122
decreased gamma-delta T cell number J:91122
thymus hypoplasia J:91122
Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:91122
decreased double-positive T cell number J:91122
thymus hypoplasia J:91122
Mybtm1Epr/Mybtm1Epr
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal T cell differentiation J:93481
decreased CD4-positive, alpha-beta T cell number J:93481
decreased double-positive T cell number J:93481
increased CD8-positive, alpha-beta T cell number J:93481
thymus hypoplasia J:93481
Mybtm1Epr/Mybtm1Epr
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal double-negative T cell morphology J:93481
abnormal T cell differentiation J:93481
decreased double-positive T cell number J:93481
thymus hypoplasia J:93481
Mybtm1Jof/Mybtm1Jof
involves: 129/Sv * C57BL/6 		abnormal B cell differentiation J:85344
abnormal definitive hematopoiesis J:85344
abnormal double-negative T cell morphology J:85344
abnormal erythropoiesis J:85344
abnormal liver development J:85344
abnormal myeloblast morphology/development J:85344
abnormal T cell differentiation J:85344
decreased body size J:85344
decreased thymocyte number J:85344
increased megakaryocyte cell number J:85344
premature death J:85344
Mybtm1Jof/Mybtm1Ssp
involves: 129/Sv * C57BL/6 		abnormal definitive hematopoiesis J:85344
abnormal erythropoiesis J:85344
abnormal liver development J:85344
abnormal myeloblast morphology/development J:85344
abnormal T cell differentiation J:85344
decreased thymocyte number J:85344
increased megakaryocyte cell number J:85344
lethality throughout fetal growth and development, complete penetrance J:85344
Mybtm1Ssp/Mybtm1Ssp
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) 		abnormal erythropoiesis J:43747
abnormal liver sinusoid morphology J:43747
anemia J:43747
decreased common myeloid progenitor cell number J:43747
decreased erythroid progenitor cell number J:43747
decreased hematocrit J:43747
decreased hematopoietic stem cell number J:43747
increased nucleated erythrocyte cell number J:43747
lethality throughout fetal growth and development, complete penetrance J:43747
pallor J:43747
small liver J:43747
Mybtm1Ssp/Mybtm1Ssp
involves: 129S2/SvPas 		abnormal angiogenesis J:63424
abnormal definitive hematopoiesis J:63424
abnormal erythropoiesis J:63424
abnormal hematopoietic stem cell morphology J:63424
Mybtm2.2Epr/Mybtm2.2Epr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal hematopoietic system phenotype J:160189
normal immune system phenotype J:160189
normal mortality/aging J:160189
Tg(CD2-Myb/en)2Kmw/?
involves: C57BL/10 * CBA 		abnormal single-positive T cell number J:126456
decreased T cell number J:126456
decreased T cell proliferation J:126456
increased double-negative T cell number J:126456
Tg(CD2-Myb/en)2Kmw/Tg(CD2-Myb/en)2Kmw
involves: C57BL/10 * CBA 		decreased body size J:126456
decreased double-positive T cell number J:126456
decreased T cell number J:126456
decreased T cell proliferation J:126456
increased double-negative T cell number J:126456
premature death J:126456
small spleen J:126456
small thymus J:126456
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory