Myb^tm1.1Jof
Targeted Allele Detail

Summary

• Symbol: Myb^tm1.1Jof
• Name: Myb proto-oncogene, transcription factor; targeted mutation 1.1, Jon Frampton
• MGI ID: MGI:3037362
• Synonyms: c-Myb^F, Myb^fl
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^tm1.1Jof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exon 3 and downstream of exon 6. In addition, an FRT flanked PGK-neo cassette was inserted in intron 6. An frt-flanked neomycin selection cassette was removed by crossing mice carrying Myb^tm1Jof to FlpE expressing mice, leaving loxP sites flanking exons 3-6. (J:85344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 56 strains or lines available

References

• Original: J:85344 Emambokus N, et al., Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003 Sep 1;22(17):4478-88
• All: 19 reference(s)