Grid2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grid2
glutamate receptor, ionotropic, delta 2
MGI:95813

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Bax^tm1Sjk/Bax⁺ Grid2^Lc-J/Grid2⁺ involves: 129X1/SvJ * BALB/cByJ * C57BL/6	abnormal cerebellar granule layer morphology	J:62117
	abnormal cerebellar Purkinje cell layer	J:62117
	ataxia	J:62117
	decreased cerebellar granule cell number	J:62117
	decreased Purkinje cell number	J:62117
	reduced cerebellar foliation	J:62117
Bax^tm1Sjk/Bax^tm1Sjk Grid2^Lc-J/Grid2⁺ involves: 129X1/SvJ * BALB/cByJ * C57BL/6	abnormal cerebellar granule layer morphology	J:62117
	abnormal cerebellar Purkinje cell layer	J:62117
	abnormal Purkinje cell dendrite morphology	J:62117
	abnormal Purkinje cell morphology	J:62117
	ataxia	J:62117
	decreased Purkinje cell number	J:62117
	normal nervous system phenotype	J:62117
Bcl2l2^{Gt(ROSA)41Sor}/Bcl2l2^{Gt(ROSA)41Sor} Grid2^ho-4J/Grid2^ho-4J involves: 129S5/SvEvBrd * DBA/2J	abnormal cerebellar Purkinje cell layer	J:137190
	abnormal cerebellum morphology	J:137190
	abnormal CNS synapse formation	J:137190
	abnormal gait	J:137190
	abnormal neuron mitochondrial morphology	J:137190
	abnormal Purkinje cell dendrite morphology	J:137190
	abnormal Purkinje cell morphology	J:137190
	ataxia	J:137190
	bradykinesia	J:137190
	decreased body size	J:137190
	decreased CNS synapse formation	J:137190
Cacna1a^tm1Kano/Cacna1a^tm1Kano Grid2^tm1(cre)Mwa/Grid2⁺ involves: C57BL/6 * C57BL/6N	abnormal CNS synaptic transmission	J:173318
	abnormal excitatory postsynaptic currents	J:173318
	abnormal neuron morphology	J:173318
	prolonged excitatory postsynaptic current decay time	J:173318
	prolonged excitatory postsynaptic current rise time	J:173318
Cacna1a^tm1Kano/Cacna1a^tm1Kano Grid2^tm1(cre)Mwa/Grid2⁺ involves: C57BL/6N	abnormal cerebellar molecular layer	J:180582
	abnormal excitatory postsynaptic current amplitude	J:180582
	abnormal Purkinje cell dendrite morphology	J:180582
	abnormal Purkinje cell morphology	J:180582
	increased neurotransmitter release	J:180582
	Purkinje cell degeneration	J:180582
	small cerebellum	J:180582
Grid2^Lc-J/Grid2⁺ Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas * 129X1/SvJ * BALB/cByJ * C57BL/6	ataxia	J:62117

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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