Cacna1a^tm1Kano
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm1Kano
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Masanobu Kano
• MGI ID: MGI:5140539
• Synonyms: Cav2.1^lox
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm1Kano page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173318
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FR-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. (J:173318)

Generation of the Cacna1a^tm1Kano allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 115 strains or lines available

References

• Original: J:173318 Hashimoto K, et al., Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9987-92
• All: 5 reference(s)