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Grid2 Gene Detail
Summary
  • Symbol
    Grid2
  • Name
    glutamate receptor, ionotropic, delta 2
  • Synonyms
    B230104L07Rik, GluRdelta2, tpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95813
    NCBI Gene: 14804
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:63232860-64681307 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 29.77 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8209 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95813
 protein coding gene Chr6:63230118-64681307 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030827
 protein coding gene Chr6:63092343-64590517 (+)
A/J MGP_AJ_G0030794
 protein coding gene Chr6:60296038-61752073 (+)
AKR/J MGP_AKRJ_G0030722
 protein coding gene Chr6:62274558-63724197 (+)
BALB/cJ MGP_BALBcJ_G0030805
 protein coding gene Chr6:60756468-62163881 (+)
C3H/HeJ MGP_C3HHeJ_G0030907
 protein coding gene Chr6:120508861-121954777 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031263
 protein coding gene Chr6:64519928-66041540 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028455
 protein coding gene Chr6:57718247-59137071 (+)
CAST/EiJ MGP_CASTEiJ_G0029917
 protein coding gene Chr6:62488521-63965769 (+)
CBA/J MGP_CBAJ_G0030492
 protein coding gene Chr6:67207811-68764503 (+)
DBA/2J MGP_DBA2J_G0030644
 protein coding gene Chr6:60045420-61450789 (+)
FVB/NJ MGP_FVBNJ_G0030597
 protein coding gene Chr6:59589364-60976948 (+)
LP/J MGP_LPJ_G0030728
 protein coding gene Chr6:63035263-64527451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030632
 protein coding gene Chr6:70653319-72520721 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031289
 protein coding gene Chr6:62208512-63678929 (+)
PWK/PhJ MGP_PWKPhJ_G0029632
 protein coding gene Chr6:59206016-60623180 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029460
 protein coding gene Chr6:61694895-63192716 (+)
WSB/EiJ MGP_WSBEiJ_G0029999
 protein coding gene Chr6:62520164-63961729 (+)



Homology
more
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRID2, glutamate ionotropic receptor delta type subunit 2
  • Synonyms
    GluD2, SCAR18
  • Links
    NCBI Gene ID: 2895
    neXtProt AC: NX_O43424
    UniProt: O43424

  • Chr Location
    4q22.1-q22.2; chr4:92304249-93810330 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Grid2 mouse models; 1 with human GRID2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 30 alleles in 31 genetic backgrounds
    24 phenotypes from multigenic genotypes
    9 images
    232 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for multiple spontaneous and targeted null mutations exhibit ataxia and impaired locomotion associated with cerebellar Purkinje cell abnormalities and loss, and on some backgrounds, male infertility due to lack of zona penetration by sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    86
  • cDNA Data
    16
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071424 Ensembl Gene Model | MGI Sequence Detail 1448448 C57BL/6J ±  kb
    transcript ENSMUST00000095852 Ensembl | MGI Sequence Detail 5860 Not Applicable  
    polypeptide ENSMUSP00000093536 Ensembl | MGI Sequence Detail 1007 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008238 glutamate receptor ionotropic, delta-2
      (term hierarchy)
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 14
      cDNA 16
      Primer pair 5
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10251, MGD-MRK-10810, MGD-MRK-11756, MGD-MRK-2116, MGI:1890672, MGI:2151352, MGI:2442634, MGI:3606121, MGI:96166, MGI:96754
    References
    more
    • Summaries
      All 317
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 19
      Phenotypes 232
    • Earliest
      J:289 Phillips RJS, "Lurcher", a new gene in linkage group XI of the house mouse. J Genet. 1960;57:35-42
    • Latest
      J:332196 Hirayama T, et al., CTCF loss induces giant lamellar bodies in Purkinje cell dendrites. Acta Neuropathol Commun. 2022 Nov 29;10(1):172
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/17/2023
    MGI 6.22     		The Jackson Laboratory