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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fkbp1a
FK506 binding protein 1a
MGI:95541
43 phenotypes from 4 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fkbp1atm1.1Shou/Fkbp1atm1.1Shou
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		abnormal heart electrocardiography waveform feature J:183588
abnormal myocardial fiber physiology J:183588
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S7/SvEvBrd * C57BL/6J * CBA/J 		normal cardiovascular system phenotype J:195489
premature death J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd 		abnormal heart ventricle morphology J:195489
lethality throughout fetal growth and development, complete penetrance J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tbx18tm2(cre)Sev/Tbx18+
involves: 129S7/SvEvBrd 		normal cardiovascular system phenotype J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Ckmm-cre)5Khn/0
involves: 129S7/SvEvBrd * FVB 		normal cardiovascular system phenotype J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Myh6-cre)2182Mds/0
involves: 129S7/SvEvBrd * FVB/N 		normal cardiovascular system phenotype J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(SLC8A1-cre)1Shou/0
involves: 129S7/SvEvBrd 		normal cardiovascular system phenotype J:195489
normal mortality/aging J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Tek-cre)1Ywa/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal cardiovascular system physiology J:195489
abnormal heart ventricle morphology J:195489
abnormal interventricular groove morphology J:195489
edema J:195489
enlarged heart J:195489
premature death J:195489
thin ventricle myocardium compact layer J:195489
ventricular septal defect J:195489
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Tg(Tnnt2-cre)5Blh/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 		normal cardiovascular system phenotype J:195489
Fkbp1atm1Grc/?
involves: 129 * 129S1/SvImJ 		no abnormal phenotype detected J:101977
Fkbp1atm1Slh/Fkbp1atm1Slh
Tg(Ckmm-cre)5Khn/0
involves: 129S7/SvEvBrd * FVB 		abnormal muscle contractility J:176731
abnormal muscle physiology J:176731
abnormal skeletal muscle morphology J:176731
impaired exercise endurance J:176731
oxidative stress J:176731
Fkbp1atm1Zuk/Fkbp1atm1Slh
Tg(Ckmm-cre)5Khn/0
involves: 129S7/SvEvBrd * FVB 		abnormal calcium ion homeostasis J:94747
abnormal muscle contractility J:94747
abnormal muscle physiology J:94747
abnormal skeletal muscle fiber morphology J:94747
abnormal skeletal muscle fiber type ratio J:94747
centrally nucleated skeletal muscle fibers J:94747
decreased body weight J:94747
Fkbp1atm1Zuk/Fkbp1atm1Zuk
either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal muscle physiology J:45536
abnormal myocardium layer morphology J:45536
abnormal trabecula carnea morphology J:45536
congestive heart failure J:45536
decreased heart left ventricle wall thickness J:45536
decreased ventricle muscle contractility J:45536
dilated cardiomyopathy J:45536
dilated heart J:45536
dilated heart atrium J:45536
dilated heart left ventricle J:45536
dilated heart right ventricle J:45536
edema J:45536
enlarged heart J:45536
exencephaly J:45536
hepatic necrosis J:45536
increased heart weight J:45536
lethality throughout fetal growth and development, incomplete penetrance J:45536
liver hemorrhage J:45536
open neural tube J:45536
pallor J:45536
perinatal lethality, incomplete penetrance J:45536
premature death J:45536
respiratory distress J:45536
ventricular septal defect J:45536
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04/30/2024
MGI 6.23 		The Jackson Laboratory