Fkbp1a^tm1Slh
Targeted Allele Detail

Summary

• Symbol: Fkbp1a^tm1Slh
• Name: FK506 binding protein 1a; targeted mutation 1, Susan L Hamilton
• MGI ID: MGI:3514012
• Synonyms: Fkbp12^Flox
• Gene: Fkbp1a Location: Chr2:151384403-151403611 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Fkbp1a^tm1Slh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94747
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The ES cell line used to create Fkbp1a^tm1Zuk (MGI:2158807)was modified so that a floxed neomycin resistance cassette could be found upstream of exon 3 and an additional loxP site was placed in the intron between exons 3 and 4. This involved the elimination of the hprt minigene in the original mutation and the restoration of exons 3 and 4. (J:94747)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1a Mutation: 14 strains or lines available

References

• Original: J:94747 Tang W, et al., Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency. FASEB J. 2004 Oct;18(13):1597-9
• All: 10 reference(s)