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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cybb
cytochrome b-245, beta polypeptide
MGI:88574
97 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cybbtm1.1Abk/Cybbtm1.1Abk
Lyz2tm1(cre)Ifo/?
B6.Cg-Lyz2tm1(cre)Ifo Cybbtm1.1Abk
abnormal cued conditioning behavior J:245699
abnormal macrophage chemotaxis J:245699
decreased body length J:245699
decreased body weight J:245699
decreased cholesterol level J:245699
decreased circulating insulin level J:245699
decreased circulating LDL cholesterol level J:245699
decreased fasting circulating glucose level J:245699
decreased fat cell size J:245699
decreased susceptibility to diet-induced obesity J:245699
decreased triglyceride level J:245699
enlarged spleen J:245699
increased brain size J:245699
increased circulating HDL cholesterol level J:245699
increased epididymal fat pad weight J:245699
Cybbtm1Din/Y
B6.129S-Cybbtm1Din
abnormal blood circulation J:138704
abnormal long-term potentiation J:147954
abnormal myocardial fiber morphology J:135786
abnormal nitric oxide homeostasis J:101981
normal cardiovascular system phenotype J:101981
decreased body weight J:135786
decreased renal plasma flow rate J:138704
decreased renal vascular resistance J:101981, J:138704
decreased right ventricle systolic pressure J:135786
decreased urine sodium level J:138704
increased renal glomerular filtration rate J:101981
increased renal plasma flow rate J:101981
increased urine creatinine level J:101981
increased urine nitrite level J:101981
increased urine sodium level J:101981
oliguria J:138704
normal renal/urinary system phenotype J:101981
Cybbtm1Din/?
B6.129S-Cybbtm1Din/J
abnormal atrioventricular cushion morphology J:306955
abnormal atrioventricular valve morphology J:306955
abnormal cardiac epithelial to mesenchymal transition J:306955
abnormal glycosaminoglycan level J:306955
abnormal heart development J:306955
abnormal heart morphology J:306955
abnormal mitral valve morphology J:306955
abnormal redox activity J:306955
abnormal tricuspid valve morphology J:306955
atrial septal defect J:306955
atrioventricular septal defect J:306955
bicuspid aortic valve J:306955
decreased birth weight J:306955
decreased cell proliferation J:306955
decreased embryo size J:306955
embryonic growth retardation J:306955
increased apoptosis J:306955
postnatal lethality, incomplete penetrance J:306955
prenatal lethality, incomplete penetrance J:306955
thick mitral valve cusps J:306955
ventricular septal defect J:306955
Cybbtm1Din/Y
involves: 129S/SvEv * C57BL/6
abnormal aorta tunica media morphology J:115614
abnormal immune system physiology J:22868
abnormal macrophage physiology J:22868
abnormal neutrophil physiology J:22868
cardiac hypertrophy J:115652
decreased body weight J:115614
decreased systemic arterial blood pressure J:115614
decreased systemic arterial systolic blood pressure J:115652
increased inflammatory response J:22868
increased susceptibility to bacterial infection J:22868
increased susceptibility to infection J:22868
Cybbtm1Din/Cybbtm1Din
B6.129S-Cybbtm1Din
abnormal spatial learning J:111410
decreased metastatic potential J:110181
decreased post-tetanic potentiation J:111410
decreased tumor growth/size J:110181
decreased vertical activity J:111410
granulomatous inflammation J:146231
normal immune system phenotype J:113463
impaired coordination J:111410
increased acute inflammation J:110181
reduced long-term potentiation J:111410
Cybbtm1Din/Cybbtm1Din
B6.129S-Cybbtm1Din/J
abnormal circulating chemokine level J:235399
abnormal kidney morphology J:235399
abnormal macrophage physiology J:235399
abnormal renal glomerulus morphology J:235399
decreased body weight J:235399
decreased circulating interleukin-10 level J:235399
glomerulonephritis J:235399
normal homeostasis/metabolism phenotype J:194294
increased anti-double stranded DNA antibody level J:235399
increased anti-nuclear antigen antibody level J:235399
increased autoantibody level J:235399
increased blood urea nitrogen level J:235399
increased circulating creatinine level J:235399
increased circulating interleukin-1 beta level J:235399
increased circulating interleukin-6 level J:235399
increased circulating interleukin-12b level J:235399
increased IgG level J:235399
increased lymphocyte cell number J:235399
increased monocyte cell number J:235399
increased neutrophil cell number J:235399
increased susceptibility to systemic lupus erythematosus J:235399
increased urine protein level J:235399
Cybbtm1Din/Cybbtm1Din
involves: 129S/SvEv * C57BL/6
abnormal aorta tunica media morphology J:115614
abnormal intestinal mucosa morphology J:64232
abnormal stomach mucosa morphology J:64232
decreased body weight J:115614
decreased systemic arterial blood pressure J:115614
normal digestive/alimentary phenotype J:64232
normal immune system phenotype J:64232
Cybbtm2b(KOMP)Wtsi/Cybbtm2b(KOMP)Wtsi
C57BL/6N-Cybbtm2b(KOMP)Wtsi/H
decreased mean corpuscular volume J:211773
increased spleen weight J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory