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Cybb Gene Detail
Summary
  • Symbol
    Cybb
  • Name
    cytochrome b-245, beta polypeptide
  • Synonyms
    Cgd, gp91phox, gp91phox, Nox2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88574
    NCBI Gene: 13058
  • Alliance
    gene page
  • Transcription Start Sites
    95 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:9301493-9354005 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 4.30 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88574
 protein coding gene ChrX:9301491-9354010 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035556
 protein coding gene ChrX:4146699-4201883 (-)
A/J MGP_AJ_G0035533
 protein coding gene ChrX:4263291-4316617 (-)
AKR/J MGP_AKRJ_G0035465
 protein coding gene ChrX:4322992-4384770 (-)
BALB/cJ MGP_BALBcJ_G0035526
 protein coding gene ChrX:4189693-4246630 (-)
C3H/HeJ MGP_C3HHeJ_G0035243
 protein coding gene ChrX:4286458-4345934 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036056
 protein coding gene ChrX:4228779-4279479 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032925
 protein coding gene ChrX:3510805-3559616 (+)
CAST/EiJ MGP_CASTEiJ_G0034535
 protein coding gene ChrX:4056000-4103435 (-)
CBA/J MGP_CBAJ_G0035212
 protein coding gene ChrX:4612821-4666863 (-)
DBA/2J MGP_DBA2J_G0035365
 protein coding gene ChrX:4194420-4248324 (-)
FVB/NJ MGP_FVBNJ_G0035312
 protein coding gene ChrX:4009238-4059149 (-)
LP/J MGP_LPJ_G0035447
 protein coding gene ChrX:4342992-4400853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035355
 protein coding gene ChrX:4461077-4515978 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036068
 protein coding gene ChrX:4113609-4168649 (-)
PWK/PhJ MGP_PWKPhJ_G0034235
 protein coding gene ChrX:3690094-3743410 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034076
 protein coding gene ChrX:4222674-4276227 (-)
WSB/EiJ MGP_WSBEiJ_G0034671
 protein coding gene ChrX:4186528-4239771 (-)



Homology
more
  • Human Ortholog
    CYBB, cytochrome b-245 beta chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYBB, cytochrome b-245 beta chain
  • Synonyms
    AMCBX2, CGD, CGDX, GP91-1, GP91PHOX, GP91-PHOX, IMD34, NOX2, p91-PHOX
  • Links
    NCBI Gene ID: 1536
    neXtProt AC: NX_P04839
    UniProt: P04839

  • Chr Location
    Xp21.1-p11.4; chrX:37780018-37813461 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cybb mouse models; 3 with human CYBB associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    97 phenotypes from 3 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    506 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show alterations in acute inflammation, synaptic plasticity, memory, metastatic potential, susceptibility to infection and induced GI injury, inflammatory response to chemical peritonitis, vascular response to Ang II, hypoxia-induced LV remodeling, and L-NAME-caused renal responses. Homozygotes for a null allele show postnatal lethality, decreased birth weight, cardiac septal and valve defects, and impaired atrioventricular cushion development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    77
  • cDNA Data
    84
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13058 NCBI Gene Model | MGI Sequence Detail 52513 C57BL/6J ±  kb
    transcript NM_007807 RefSeq | MGI Sequence Detail 4750 C57BL/6  
    polypeptide Q61093 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 87
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1965, MGD-MRK-2263, MGI:2148082
    References
    more
    • Summaries
      All 651
      Developmental Gene Expression 13
      Diseases 4
      Gene Ontology 14
      Phenotypes 506
    • Earliest
      J:9438 Ryder-Cook AS, et al., Localization of the mdx mutation within the mouse dystrophin gene. EMBO J. 1988 Oct;7(10):3017-21
    • Latest
      J:347028 Ma Y, et al., NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy. Sci Rep. 2024 Mar 23;14(1):6971
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory