Symbol
Name
ID

Cybb
cytochrome b-245, beta polypeptide
MGI:88574

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Deficiency or absence of cytochrome b(-245)	Decreased activity of NADPH oxidase	Pleural effusion	Fever	Ascites
Disease(s) Associated with CYBB	Deficiency or absence of cytochrome b(-245)	Decreased activity of NADPH oxidase	Pleural effusion	Fever	Ascites
chronic granulomatous disease
X-linked chronic granulomatous disease

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased susceptibility to diet-induced obesity

increased circulating creatinine level

increased urine creatinine level

increased blood urea nitrogen level

decreased fasting circulating glucose level

decreased circulating insulin level

increased circulating HDL cholesterol level

decreased circulating LDL cholesterol level

abnormal circulating chemokine level

increased circulating interleukin-1 beta level

decreased circulating interleukin-10 level

increased circulating interleukin-12b level

increased circulating interleukin-6 level

abnormal nitric oxide homeostasis

abnormal glycosaminoglycan level

decreased urine sodium level

increased urine sodium level

decreased cholesterol level

decreased triglyceride level

increased urine nitrite level

increased urine protein level

Availability

Mouse Genotype

Cybb^tm1Din/Cybb^tm1Din

Cybb^tm1Din/Y

Cybb^tm1Din/?

Cybb^tm1.1Abk/Cybb^tm1.1Abk
Lyz2^tm1(cre)Ifo/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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