111 phenotypes from 10 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr1tm1.1(KOMP)Vlcg/Acvr1+ C57BL/6N-Acvr1tm1.1(KOMP)Vlcg/MbpMmucd	increased circulating total protein level	J:211773
Acvr1tm1.1(KOMP)Vlcg/Acvr1tm1.1(KOMP)Vlcg C57BL/6N-Acvr1tm1.1(KOMP)Vlcg/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Acvr1tm1.1Mak/Acvr1tm1.1Mak involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal embryo development	J:285841
	prenatal lethality, complete penetrance	J:285841
Acvr1tm1.1Vk/Acvr1tm1.1Vk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal embryonic epiblast morphology	J:117234
	abnormal gastrulation	J:117234
	abnormal mesoderm development	J:117234
	abnormal primitive streak morphology	J:117234
	decreased embryo size	J:117234
	embryonic growth arrest	J:117234
Acvr1tm1Bhr/Acvr1tm1Bhr involves: 129S7/SvEvBrd * C57BL/6	abnormal embryonic epiblast morphology	J:57670
	abnormal mesoderm development	J:57670
	abnormal primitive streak formation	J:57670
	absent allantois	J:57670
	decreased embryo size	J:57670
	disorganized embryonic tissue	J:57670
	embryonic growth arrest	J:57670
	embryonic lethality between implantation and somite formation, complete penetrance	J:57670
Acvr1tm1Bhr/Acvr1tm1Bhr involves: 129S7/SvEvBrd * C57BL/6J	abnormal embryonic epiblast morphology	J:117234
	abnormal gastrulation	J:117234
	abnormal mesoderm development	J:117234
	abnormal primitive streak morphology	J:117234
	decreased embryo size	J:117234
	embryonic growth arrest	J:117234
Acvr1tm1Emsh/Acvr1+ C57BL/6-Acvr1tm1Emsh	neonatal lethality, complete penetrance	J:194134
Acvr1tm1Emsh/Acvr1+ chimera involves: BALB/c * C57BL/6 * CD-1	abnormal cervical vertebrae morphology	J:194134
	abnormal costovertebral joint morphology	J:194134
	abnormal joint mobility	J:194134
	abnormal joint morphology	J:194134
	abnormal motor capabilities/coordination/movement	J:194134
	abnormal phalanx morphology	J:194134
	broad femur neck	J:194134
	ectopic bone	J:194134
	edema	J:194134
	increased apoptosis	J:194134
	increased inflammatory response	J:194134
	increased osteochondroma incidence	J:194134
	short femur neck	J:194134
	short metatarsal bones	J:194134
	skeletal muscle degeneration	J:194134
	vertebral fusion	J:194134
Acvr1tm1Enl/Acvr1tm1Enl involves: 129S4/SvJae * BALB/c	abnormal ectoderm development	J:54394
	abnormal embryo development	J:54394
	abnormal gastrulation	J:54394
	abnormal primitive streak formation	J:54394
	abnormal visceral endoderm morphology	J:54394
	absent allantois	J:54394
	absent amnion	J:54394
	absent amniotic folds	J:54394
	absent chorion	J:54394
	absent mesoderm	J:54394
	decreased embryo size	J:54394
	embryonic lethality during organogenesis, complete penetrance	J:54394
	thick embryonic epiblast	J:54394
Acvr1tm1Glh/Acvr1+ Tg(Cdh5-cre)7Mlia/0 involves: 129S6/SvEvTac * C57BL/6J * FVB/N	normal skeleton phenotype	J:257905
Acvr1tm1Glh/Acvr1+ Myod1tm2.1(icre)Glh/Myod1+ involves: 129S6/SvEvTac * C57BL/6J * FVB/N	normal skeleton phenotype	J:257905
Acvr1tm1Mak/Acvr1+ Olig2tm1.1(cre)Wdr/Olig2+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal brain development	J:285841
	abnormal brainstem morphology	J:285841
	abnormal glial cell physiology	J:285841
	ataxia	J:285841
	muscle spasm	J:285841
	normal neoplasm	J:285841
	preweaning lethality, incomplete penetrance	J:285841
Acvr1tm1Vk/Acvr1tm1.1Vk H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal aortic arch and aortic arch branch attachment	J:90988
	abnormal aortic arch morphology	J:90988
	abnormal brachiocephalic trunk morphology	J:90988
	abnormal cardiac neural crest cell migration	J:90988
	abnormal cardiac outflow tract development	J:90988
	abnormal cartilage morphology	J:90453
	abnormal frontal bone squamous part morphology	J:90453
	abnormal malleus morphology	J:90453
	abnormal mandible morphology	J:90453
	abnormal mandibular fossa morphology	J:90453
	abnormal Meckel's cartilage morphology	J:90453
	abnormal palatal shelf elevation	J:90453
	abnormal pharyngeal arch artery morphology	J:90988
	abnormal sixth pharyngeal arch artery morphology	J:90988
	abnormal suckling behavior	J:90453
	abnormal third pharyngeal arch artery morphology	J:90988
	abnormal zygomatic arch morphology	J:90453
	absent cardiac neural crest cells	J:90988
	absent mandibular symphysis	J:90453
	absent retrotympanic process	J:90453
	absent temporal bone zygomatic process	J:90453
	absent temporomandibular joint	J:90453
	absent zygomatic bone	J:90453
	cleft secondary palate	J:90453
	conotruncal ridge hypoplasia	J:90988
	decreased cardiac neural crest cell number	J:90988
	delayed palatal shelf elevation	J:90453
	enlarged heart	J:90988
	impaired cardiac neural crest cell differentiation	J:90988
	increased heart right ventricle size	J:90988
	large anterior fontanelle	J:90453
	lethality throughout fetal growth and development, incomplete penetrance	J:90453, J:90988
	mandible hypoplasia	J:90453
	neonatal lethality, complete penetrance	J:90988
	persistent truncus arteriosus	J:90988
	retroesophageal right subclavian artery	J:90988
	short malleus manubrium	J:90453
	short mandible	J:90453
	shortened head	J:90453
	small mandibular coronoid process	J:90453
	small temporal bone squamous part	J:90453
	ventricular septal defect	J:90988
Acvr1tm1Vk/Acvr1tm1.1Vk Tg(Myh6-cre)2182Mds/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	normal cardiovascular system phenotype	J:103532
Acvr1tm1Vk/Acvr1tm1.1Vk Tg(Tek-cre)12Flv/0 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	abnormal atrioventricular cushion morphology	J:103532
	abnormal atrioventricular septum morphology	J:103532
	abnormal atrioventricular valve development	J:103532
	abnormal cardiac epithelial to mesenchymal transition	J:103532
	abnormal heart morphology	J:103532
	abnormal vascular endothelial cell differentiation	J:103532
	atrial septal defect	J:103532
	cardiovascular shunt	J:103532
	decreased atrioventricular cushion size	J:103532
	lethality throughout fetal growth and development, incomplete penetrance	J:103532
	ventricular septal defect	J:103532
Acvr1tm2.1Vlcg/Acvr1+ Tg(Prrx1-cre)1Cjt/0 involves: C57BL/6J * C57BL/6NTac * SJL/J	abnormal digit morphology	J:239136
	abnormal long bone epiphyseal plate morphology	J:239136
	abnormal motor capabilities/coordination/movement	J:239136
	abnormal skeleton development	J:239136
	decreased length of long bones	J:239136
	decreased width of hypertrophic chondrocyte zone	J:239136
	increased bone ossification	J:239136
	increased chondrocyte proliferation	J:239136
	short femur	J:239136
	short humerus	J:239136
	short radius	J:239136
	short tibia	J:239136
Acvr1tm2.1Vlcg/Acvr1+ Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac	increased bone ossification	J:234069