Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3.1, Velocigene
• MGI ID: MGI:5545927
• Synonyms: Gt(ROSA)26Sor^CreERt2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200671
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: The targeted construct introcuded into the locus a fusion between phage cre and a modified estrogen receptor (ERT2) and an FRT-flanked hygromycin resistance cassette. Flp-mediated recombination removed the hygromycin resistance cassette. (J:200671)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

Notes

This allele was originally generated in ES cells containing Dll4^tm2.1Vlcg.

References

• Original: J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
• All: 6 reference(s)