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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg
targeted mutation 3.1, Velocigene
MGI:5545927
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Acvr1tm2.1Vlcg/Acvr1+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac MGI:5825038
cn2
 		Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546217
cn3
 		Dll4tm3.1Vlcg/Dll4+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546218
cn4
 		Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546225
cn5
 		Droshatm1.1Vlcg/Droshatm3Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546236


Genotype
MGI:5825038
cn1
Allelic
Composition		 Acvr1tm2.1Vlcg/Acvr1+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm2.1Vlcg mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased bone ossification ( J:234069 )
• as early as 2 weeks, tamoxifen-treated mice exhibit progressive, heterotopic ossification (HO) in the sternum, caudal vertebrae, hip joint and hindlimb resulting in fusion between the heterotropic bone and native skeletal elements
• mature heterotropic bone contain bone marrow and resemble normal bone
• however, treatment with broad-acting BMP and activin blockers ACVR2A-Fc and ACVR2B-Fc, alone or in combination, inhibits or ameliorates HO phenotype

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
fibrodysplasia ossificans progressiva DOID:13374 OMIM:135100
 J:234069




Genotype
MGI:5546217
cn2
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:200671 )
• abrogated maturation in mice treated with tamoxifen at P5

vision/eye
abnormal retina vasculature morphology ( J:200671 )
• abrogated maturation in mice treated with tamoxifen at P5




Genotype
MGI:5546218
cn3
Allelic
Composition		 Dll4tm3.1Vlcg/Dll4+
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm3.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5546225
cn4
Allelic
Composition		 Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes

nervous system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes




Genotype
MGI:5546236
cn5
Allelic
Composition		 Droshatm1.1Vlcg/Droshatm3Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1.1Vlcg mutation (0 available); any Drosha mutation (96 available)
Droshatm3Vlcg mutation (0 available); any Drosha mutation (96 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:200671 )
N
• tamoxifen-treated mice are born and survive

growth/size/body
decreased body size ( J:200671 )
• tamoxifen-treated mice are runted




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory