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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Acr
acrosin prepropeptide
MGI:87884
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Acrtm1Wen/\Acrtm1Wen
\H1f1tm1Drab/\H1f1tm1Drab
\Smcptm1Wen/\Smcptm1Wen
involves: 129/Sv * C57BL/6J * CD-1 		asthenozoospermia J:98301
impaired binding of sperm to zona pellucida J:98301
impaired fertilization J:98301
reduced male fertility J:98301
\Acrtm1Wen/\Acrtm1Wen
\H1f1tm1Drab/\H1f1tm1Drab
\Tnp2tm1Wen/\Tnp2tm1Wen
involves: 129 * C57BL/6J * CD-1b 		no abnormal phenotype detected J:86670
\Acrtm1Wen/\Acrtm1Wen
\H1f6tm1Ais/\H1f6tm1Ais
\Tnp2tm1Wen/\Tnp2tm1Wen
involves: 129/Sv * C57BL/6J * CD-1 * SJL 		no abnormal phenotype detected J:86670
\Acrtm1Wen/\Acrtm1Wen
\H1f6tm1Drab/\H1f6tm1Drab
\Smcptm1Wen/\Smcptm1Wen
involves: 129/Sv * C57BL/6J * CD-1 		abnormal sperm head morphology J:98301
asthenozoospermia J:98301
impaired binding of sperm to zona pellucida J:98301
impaired fertilization J:98301
impaired sperm migration in female genital tract J:98301
reduced male fertility J:98301
\Acrtm1Wen/\Acrtm1Wen
\Smcptm1Wen/\Smcptm1Wen
\Tnp2tm1Wen/\Tnp2tm1Wen
involves: 129/Sv * C57BL/6J * CD-1 		asthenozoospermia J:98301
impaired binding of sperm to zona pellucida J:98301
impaired sperm migration in female genital tract J:98301
male infertility J:98301
\Phf7em2Osb/\Phf7em2Osb
\Tg(CAG-EGFP,Acr-EGFP)2Osb/0
involves: 129S2/SvPas * C57BL/6NSlc 		abnormal sperm nucleus morphology J:298823
asthenozoospermia J:298823
decreased fertilization frequency J:298823
male infertility J:298823
oligozoospermia J:298823
teratozoospermia J:298823
\Tex101tm1Osb/\Tex101tm1Osb
\Tg(CAG-EGFP,Acr-EGFP)2Osb/\Tg(CAG-EGFP,Acr-EGFP)2Osb
involves: C57BL/6NSlc 		abnormal acrosome reaction J:197323
abnormal hyperactivated sperm motility J:197323
normal behavior/neurological phenotype J:197323
impaired binding of sperm to zona pellucida J:197323
impaired sperm migration in female genital tract J:197323
male infertility J:197323
normal reproductive system phenotype J:197323
\Zfp541em1Osb/\Zfp541em1Osb
\Tg(CAG-EGFP,Acr-EGFP)2Osb/0
involves: 129S2/SvPas * C57BL/6NSlc 		abnormal male meiosis J:306305
abnormal synaptonemal complex J:306305
abnormal X-Y chromosome synapsis during male meiosis J:306305
arrest of male meiosis J:306305
decreased round spermatid number J:306305
increased primordial germ cell apoptosis J:306305
male infertility J:306305
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory