H1f6^tm1Ais
Targeted Allele Detail

Summary

• Symbol: H1f6^tm1Ais
• Name: H1.6 linker histone, cluster member; targeted mutation 1, Art I Skoultchi
• MGI ID: MGI:2386872
• Synonyms: H1t^-
• Gene: H1f6 Location: Chr13:23879794-23880528 bp, + strand Genetic Position: Chr13, 9.88 cM, cytoband A3.2
• Alliance: H1f6^tm1Ais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60600
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the entire gene and the flanking noncoding regions were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by reverse-phase HPLC and mass spectrograph analysis of total histone extracts from germ cell chromatin. (J:60600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H1f6 Mutation: 17 strains or lines available

References

• Original: J:60600 Lin Q, et al., Normal spermatogenesis in mice lacking the testis-specific linker histone H1t. Mol Cell Biol. 2000 Mar;20(6):2122-8
• All: 2 reference(s)