Ppargc1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
MGI:2444934

52 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ppargc1b^tm1.1Avp/Ppargc1b^tm1.1Avp involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6	abnormal metabolism	J:116167
	abnormal myocardial fiber mitochondrial morphology	J:116167
	abnormal skeletal muscle fiber mitochondrial morphology	J:116167
	abnormal white adipose tissue morphology	J:116167
	decreased body weight	J:116167
	decreased circulating cholesterol level	J:116167
	decreased circulating triglyceride level	J:116167
	decreased gonadal fat pad weight	J:116167
	decreased heart rate	J:116167
	decreased oxygen consumption	J:116167
	decreased white adipose tissue amount	J:116167
	hepatic steatosis	J:116167
	increased liver weight	J:116167
	increased white fat cell size	J:116167
Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk involves: 129X1/SvJ * FVB/N	abnormal brown adipose tissue morphology	J:137598
	abnormal fat cell morphology	J:137598
	abnormal muscle physiology	J:137598
	normal adipose tissue phenotype	J:137598
	normal cardiovascular system phenotype	J:137598
	decreased survivor rate	J:137598
	decreased triglyceride level	J:137598
	impaired adaptive thermogenesis	J:137598
	impaired exercise endurance	J:137598
	normal muscle phenotype	J:137598
	postnatal lethality	J:137598
Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi Tg(Fabp4-cre)1Rev/? involves: 129P2/OlaHsd * C57BL/6J	abnormal brown fat cell morphology	J:221221
	abnormal mitochondrial physiology	J:221221
	abnormal oxidative phosphorylation	J:221221
	abnormal respiratory electron transport chain	J:221221
	abnormal tricarboxylic acid cycle	J:221221
	normal adipose tissue phenotype	J:221221
	normal behavior/neurological phenotype	J:221221
	decreased brown fat lipid droplet number	J:221221
	normal growth/size/body region phenotype	J:221221
	normal homeostasis/metabolism phenotype	J:221221
	increased brown adipose tissue amount	J:221221
	increased brown fat cell lipid droplet size	J:221221
Ppargc1b^tm1.1Rev/Ppargc1b^tm1.1Rev involves: 129 * C57BL/6J	decreased circulating free fatty acids level	J:120079
	decreased circulating triglyceride level	J:120079
	decreased locomotor activity	J:120079
	normal homeostasis/metabolism phenotype	J:120079
	impaired adaptive thermogenesis	J:120079
	increased circulating free fatty acids level	J:120079
	increased circulating triglyceride level	J:120079
	increased liver triglyceride level	J:120079
	increased liver weight	J:120079
	macrovesicular hepatic steatosis	J:120079
	postnatal lethality, incomplete penetrance	J:120079
Ppargc1b^tm1.2Rev/Ppargc1b^tm1.2Rev Tg(Tek-cre)1Ywa/0 involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	abnormal osteoclast differentiation	J:160910
	decreased bone resorption	J:160910
Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl involves: C57BL/6	abnormal mitochondrial morphology	J:129775
	abnormal mitochondrial physiology	J:129775
	increased liver triglyceride level	J:129775
	insulin resistance	J:129775
Tg(Ckm-Ppargc1b)T37Brsp/0 FVB-Tg(Ckm-Ppargc1b)T37Brsp	abnormal mitochondrial morphology	J:118258
	abnormal muscle physiology	J:118258
	abnormal skeletal muscle fiber type ratio	J:118258
	abnormal skeletal muscle morphology	J:118258
	decreased skeletal muscle fiber size	J:118258
	enhanced exercise endurance	J:118258
	skeletal muscle hypoplasia	J:118258

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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