Ppargc1b^tm1Lowl
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1Lowl
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation Bradford B Lowell
• MGI ID: MGI:3771174
• Synonyms: Pgc-1beta^E3,4-
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neo cassette to create a hypomorphic allele. Exons 3 and 4 encode two of three LXXLL motifs. The production of the altered portein product was confirmed by western blot analysis on brown adipose tissue extracts. (J:129775)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 56 strains or lines available

References

• Original: J:129775 Vianna CR, et al., Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec;4(6):453-64
• All: 2 reference(s)