Phenotypes associated with this allele

• Allele Symbol: Ppargc1b^tm1Lowl
• Allele Name: targeted mutation Bradford B Lowell
• Allele ID: MGI:3771174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl	involves: C57BL/6	MGI:3771176

Genotype
MGI:3771176

hm1

• Allelic Composition: Ppargc1b^tm1Lowl/Ppargc1b^tm1Lowl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

insulin resistance ( J:129775 )

• mice exhibit hepatic insulin resistance

• however, skeletal muscles do not exhibit insulin resistance

increased liver triglyceride level ( J:129775 )

• hepatic triglyceride levels are increased (7.76+/-0.75 mg/g compared to 3.82+/-0.58 mg/g in wild-type mice)

cellular

abnormal mitochondrial morphology ( J:129775 )

• liver and muscle exhibit decreased mitochondrial area and function

abnormal mitochondrial physiology ( J:129775 )

• liver and muscle exhibit decreased mitochondrial area and function

liver/biliary system

increased liver triglyceride level ( J:129775 )

• hepatic triglyceride levels are increased (7.76+/-0.75 mg/g compared to 3.82+/-0.58 mg/g in wild-type mice)