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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mob1a
MOB kinase activator 1A
MGI:2442631
51 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccn2tm1.1Alea/Ccn2tm1.1Alea
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Albtm1(cre/ERT2)Mtz/Alb+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		increased hepatobiliary system tumor incidence J:228499
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn 		abdomen swellings J:228499
abnormal bile duct physiology J:228499
abnormal cholangiocyte morphology J:228499
enlarged liver J:228499
increased cholangiocarcinoma incidence J:228499
increased circulating bilirubin level J:228499
increased hepatobiliary system tumor incidence J:228499
increased hepatocellular carcinoma incidence J:228499
increased hepatocyte number J:228499
increased hepatocyte proliferation J:228499
increased liver adenoma incidence J:228499
jaundice J:228499
liver fibrosis J:228499
normal liver/biliary system phenotype J:228499
postnatal lethality, incomplete penetrance J:228499
premature death J:228499
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Tg(KRT14-cre/ERT)20Efu/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal autopod morphology J:193981
abnormal cell nucleus morphology J:193981
abnormal ear morphology J:193981
abnormal keratinocyte morphology J:193981
abnormal keratinocyte physiology J:193981
abnormal lip morphology J:193981
abnormal mitosis J:193981
abnormal mitotic spindle morphology J:193981
abnormal mouth morphology J:193981
decreased body size J:193981
decreased keratinocyte apoptosis J:193981
dysphagia J:193981
epidermal hyperplasia J:193981
increased epidermal stem cell number J:193981
increased keratinocyte proliferation J:193981
parakeratosis J:193981
postnatal lethality, complete penetrance J:193981
premature death J:193981
ruffled hair J:193981
wrinkled skin J:193981
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Wwtr1tm1Hku/Wwtr1tm1Hku
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA 		abnormal cholangiocyte morphology J:228499
increased liver weight J:228499
liver fibrosis J:228499
Mob1atm1.2Asuz/Mob1a+
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal orientation of inner hair cell stereociliary bundles J:193981
exostosis J:193981
impaired balance J:193981
increased fibrosarcoma incidence J:193981
increased integument system tumor incidence J:193981
increased mammary gland tumor incidence J:193981
increased osteosarcoma incidence J:193981
increased salivary gland tumor incidence J:193981
increased skin tumor incidence J:193981
increased trabecular bone thickness J:193981
malocclusion J:193981
Mob1atm1.2Asuz/Mob1atm1.2Asuz
Mob1bGt(CC0690)Wtsi/Mob1b+
involves: 129P2/OlaHsd * C57BL/6 		abnormal orientation of inner hair cell stereociliary bundles J:193981
exostosis J:193981
impaired balance J:193981
increased fibrosarcoma incidence J:193981
increased integument system tumor incidence J:193981
increased liver tumor incidence J:193981
increased lung tumor incidence J:193981
increased mammary gland tumor incidence J:193981
increased osteosarcoma incidence J:193981
increased salivary gland tumor incidence J:193981
increased skin tumor incidence J:193981
increased trabecular bone thickness J:193981
malocclusion J:193981
Mob1atm1.2Asuz/Mob1atm1.2Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:193981
abnormal mitosis J:193981
absent inner cell mass proliferation J:193981
embryonic lethality between implantation and placentation, complete penetrance J:193981
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory